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Is melia azadirachta leaf extract safe during pregnancy?

Reviewed by · Last reviewed

Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
melia azadirachta leaf extract
HIGH RISK
20
/100
0

Pregnancy-Safe Alternatives to melia azadirachta leaf extract | VeriMom

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Frequently asked questions

Is melia azadirachta leaf extract safe during pregnancy?
Neem (Azadirachta indica) is documented as abortifacient, anti-implantation, and anti-fertility in peer-reviewed literature. Listed as "Likely Unsafe" in pregnancy by NMCD/LactMed. Oral and topical use during pregnancy is contraindicated.
Is melia azadirachta leaf extract safe while breastfeeding?
Breastfeeding: same hazard and mechanism as pregnancy because reproductive/endocrine-active constituents (notably limonoids/azadirachtin in neem) have demonstrated reproductive effects in animals. Dermal exposure from cosmetics is low but not zero; systemic transfer to breastmilk after topical use has not been quantified, so exposure rated as low but measurable (e=1). No high-quality human lactation studies found.
Is melia azadirachta leaf extract safe for baby skin?
For infants (0–3 yr) the underlying hazard and mechanism remain 'suspected' (h=2, m=2) based on animal reproductive/endocrine findings for neem extracts. Exposure score increased by +1 relative to adult because infant skin has higher surface-area-to-weight and an immature barrier, so dermal absorption and systemic dose per kg are higher (adult e=1 → infant e=2). Additionally, neem extracts are reported skin sensitizers in some contexts. No infant-specific safety trials were identified.
How does VeriMom score melia azadirachta leaf extract?
VeriMom scores melia azadirachta leaf extract at 20/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
What are pregnancy-safe alternatives to melia azadirachta leaf extract?
See our curated list of pregnancy-safe alternatives to melia azadirachta leaf extract based on similar function and a no-known-risks safety band.

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Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.

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