VeriMomIs isopropylidenediphenol diglycidyl ether safe during pregnancy?
ECHA Annex VI (harmonised CLP) assigns H315, H319, H317 (skin/eye irritation and skin sensitisation) to this substance (listed as bis-[4-(2,3-epoxipropoxi)phenyl]propane) but does NOT include any reproductive classifications (H360/H361). There are no authoritative reproductive/toxicology classifications cited for this substance; however, the chemical is a diglycidyl ether of a bisphenol-type scaffold which gives a theoretical (structural) concern for endocrine activity (mechanism=1) but no direct reproductive data to raise hazard (h=0). Estimated dermal systemic exposure from cosmetic topical use is low but measurable (e=1) based on its use as an epoxy-diglycidyl ether and skin reactivity (H317). Sources: ECHA Annex VI (harmonised CLP), ECHA H-codes.
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Frequently asked questions
- Is isopropylidenediphenol diglycidyl ether safe during pregnancy?
- ECHA Annex VI (harmonised CLP) assigns H315, H319, H317 (skin/eye irritation and skin sensitisation) to this substance (listed as bis-[4-(2,3-epoxipropoxi)phenyl]propane) but does NOT include any reproductive classifications (H360/H361). There are no authoritative reproductive/toxicology classifications cited for this substance; however, the chemical is a diglycidyl ether of a bisphenol-type scaffold which gives a theoretical (structural) concern for endocrine activity (mechanism=1) but no direct reproductive data to raise hazard (h=0). Estimated dermal systemic exposure from cosmetic topical use is low but measurable (e=1) based on its use as an epoxy-diglycidyl ether and skin reactivity (H317). Sources: ECHA Annex VI (harmonised CLP), ECHA H-codes.
- Is isopropylidenediphenol diglycidyl ether safe while breastfeeding?
- No reproductive or lactation-specific toxicology or human data identified in the authoritative regulatory classification. Theoretical structural concern exists because the molecule is a bisphenol-derived diglycidyl ether (mechanism=1) but there is no direct evidence of transfer into milk or lactation toxicity (h=0). Systemic exposure after dermal cosmetic use is expected low but measurable (e=1). Sources: ECHA Annex VI (harmonised CLP), ECHA H-codes.
- Is isopropylidenediphenol diglycidyl ether safe for baby skin?
- Harmonised ECHA classification addresses skin irritation, eye irritation and sensitisation only; no harmonised reproductive or developmental hazard is assigned (h=0). Mechanistic concern remains theoretical due to the bisphenol-type structure (m=1). Dermal exposure potential is higher in infants because of thinner barrier and higher surface area-to-body-weight; therefore exposure score is increased by +1 compared with adults (adult e=1 → infant e=2). No infant-specific toxicokinetic or safety studies were identified. Sources: ECHA Annex VI (harmonised CLP), ECHA H-codes.
- How does VeriMom score isopropylidenediphenol diglycidyl ether?
- VeriMom scores isopropylidenediphenol diglycidyl ether at 87/100 (low risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to isopropylidenediphenol diglycidyl ether?
- See our curated list of pregnancy-safe alternatives to isopropylidenediphenol diglycidyl ether based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.