VeriMomIs iodopropynyl butylcarbamate safe during pregnancy?
ECHA (harmonised CLP, Commission Delegated Regulation amending Annex VI / 23rd ATP, 2025) lists 3‑iodo‑2‑propynyl butylcarbamate (IPBC; CAS 55406‑53‑6) with a reproductive classification (suspected effect on fertility; H361f), which by your scoring rules maps to h=2. The Cosmetic Ingredient Review (CIR) safety assessment (re‑review) concluded IPBC is 'safe as used' at low cosmetic concentrations (≤0.1%) but noted use restrictions and that most use concentrations are ≈0.01% and one regulatory label warning 'Not to be used for children under 3 years of age'; topical exposure from cosmetics is therefore low but measurable (evidence: CIR absorption/distribution discussion). Sources: ECHA/Official Journal harmonised CLP and CIR review.
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Frequently asked questions
- Is iodopropynyl butylcarbamate safe during pregnancy?
- ECHA (harmonised CLP, Commission Delegated Regulation amending Annex VI / 23rd ATP, 2025) lists 3‑iodo‑2‑propynyl butylcarbamate (IPBC; CAS 55406‑53‑6) with a reproductive classification (suspected effect on fertility; H361f), which by your scoring rules maps to h=2. The Cosmetic Ingredient Review (CIR) safety assessment (re‑review) concluded IPBC is 'safe as used' at low cosmetic concentrations (≤0.1%) but noted use restrictions and that most use concentrations are ≈0.01% and one regulatory label warning 'Not to be used for children under 3 years of age'; topical exposure from cosmetics is therefore low but measurable (evidence: CIR absorption/distribution discussion). Sources: ECHA/Official Journal harmonised CLP and CIR review.
- Is iodopropynyl butylcarbamate safe while breastfeeding?
- Because a harmonised classification for suspected reproductive/fertility effects (H361f) applies to the substance, breastfeeding context follows the same hazard score (h=2) in absence of infant‑specific reproductive transfer data. No robust published evidence was found demonstrating a specific reproductive mechanism or established lactational transfer, so m=0. Dermal cosmetic exposure to a lactating mother is low but measurable at typical cosmetic concentrations (e=1).
- Is iodopropynyl butylcarbamate safe for baby skin?
- Hazard remains driven by the harmonised classification (h=2). No infant‑specific mechanistic evidence was identified (m=0). Exposure score is increased by +1 for baby skin per your rules because IPBC has measurable dermal exposure from cosmetics and infant skin has an immature barrier, so e=2. CIR and EU restrictions explicitly include a label warning 'Not to be used for children under 3 years of age', supporting extra caution for 0–3 y.
- How does VeriMom score iodopropynyl butylcarbamate?
- VeriMom scores iodopropynyl butylcarbamate at 53/100 (medium risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to iodopropynyl butylcarbamate?
- See our curated list of pregnancy-safe alternatives to iodopropynyl butylcarbamate based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.