Is tetrahydrofurfuryl alcohol safe during pregnancy?

Pregnancy-Safe Alternatives to tetrahydrofurfuryl alcohol | VeriMom

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See also

• Is tetrahydrofurfuryl alcohol safe for babies?
• Should I avoid tetrahydrofurfuryl alcohol during pregnancy?
• What are pregnancy-safe alternatives to tetrahydrofurfuryl alcohol?

Frequently asked questions

Is tetrahydrofurfuryl alcohol safe during pregnancy?

ECHA lists tetrahydrofurfuryl alcohol (CAS 97-99-4) with a harmonised classification Repr. 1B H360Df (may damage the unborn child), which is legally binding in the EU and justifies a Category 1 CMR hazard (h=3). Reproductive/developmental effects are reported in an OECD-style rat screening study (reduced pups, resorptions, effects on parental reproductive organs; NOAELs reported), supporting demonstrated in vivo developmental toxicity (m=2). For typical topical cosmetic use systemic absorption is possible but not expected to be high; therefore exposure for a cosmetic user is scored as low-to-measurable (e=1). Sources: ECHA harmonised classification and rat reproduction screening study.

Is tetrahydrofurfuryl alcohol safe while breastfeeding?

Harmonised Repr. 1B (H360Df) applies irrespective of exposure route and therefore indicates a high hazard for lactating people (h=3). Mechanistic evidence is from in vivo reproductive/developmental findings in animals (m=2). There are no high-quality lactation-transfer data; for typical cosmetic topical use systemic exposure is likely low-to-measurable (e=1), but if significant systemic exposure occurs transfer to milk cannot be ruled out.

Is tetrahydrofurfuryl alcohol safe for baby skin?

Hazard remains high (h=3) because of the harmonised H360Df classification. Mechanistic rating is based on demonstrated in vivo developmental/reproductive effects in animals (m=2). Exposure for infants 0–3 years is increased by one point per your instructions because of immature barrier and higher SA:BW; therefore e is increased to 2 (moderate exposure potential) even if adult topical exposure would be low.

How does VeriMom score tetrahydrofurfuryl alcohol?

VeriMom scores tetrahydrofurfuryl alcohol at 20/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.

What are pregnancy-safe alternatives to tetrahydrofurfuryl alcohol?

See our curated list of pregnancy-safe alternatives to tetrahydrofurfuryl alcohol based on similar function and a no-known-risks safety band.