Is polyquaternium-28 safe during pregnancy?
Reviewed by VeriMom Editorial Team · Last reviewed
Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
polyquaternium-28
NO KNOWN RISKS100
/100
0









Pregnancy-safe products containing polyquaternium-28

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Frequently asked questions
- Is polyquaternium-28 safe during pregnancy?
- No harmonised CLP reproductive classification on ECHA Annex VI for polyquaternium-28, no SCCS/CIR safety assessment indicating reproductive hazard, and no peer-reviewed reports of developmental or reproductive toxicity identified. Polyquaternium-28 is a high‑MW quaternary ammonium polymer (low systemic absorption expected from topical use), so default hazard/mechanism scores are 0 (sources: ECHA Annex VI, PubChem, CosIng, PubMed search showed no reproductive/toxicity signals).
- Is polyquaternium-28 safe while breastfeeding?
- No evidence of reproductive or lactation-specific toxicity or harmonised classification; as a large polymeric conditioning agent, systemic exposure following topical use is expected to be negligible and no mechanistic data indicate transfer into milk (sources: ECHA Annex VI, PubChem, CosIng, EWG).
- Is polyquaternium-28 safe for baby skin?
- Hazard and mechanism: no reproductive/toxic signals specific to infants found. Exposure: increased by one (e=1) relative to adults because polyquaternium-28 is a polymer with low but not zero potential for percutaneous uptake; infant skin barrier immaturity and higher surface‑area‑to‑weight justify a conservative increase in exposure scoring (sources: PubChem, CosIng, general dermal absorption principles).
- How does VeriMom score polyquaternium-28?
- VeriMom scores polyquaternium-28 at 100/100 (no known risks) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to polyquaternium-28?
- See our curated list of pregnancy-safe alternatives to polyquaternium-28 based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.