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Is poloxamer 182 safe during pregnancy?

Reviewed by · Last reviewed

Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
poloxamer 182
NO KNOWN RISKS
100
/100
0

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Frequently asked questions

Is poloxamer 182 safe during pregnancy?
Poloxamer 182 (a polyethylene–polypropylene block copolymer, trade family Pluronic/Poloxamer) has no harmonised reproductive classification on ECHA Annex VI and no credible peer-reviewed or regulatory evidence of reproductive toxicity. Poloxamers are large, nonionic polymers with low dermal penetration and are generally regarded as safe for topical use in cosmetics (CosIng, PubChem, ECHA registration data).
Is poloxamer 182 safe while breastfeeding?
No data indicate reproductive or lactation-specific toxicity and the high molecular weight and hydrophilic character make systemic absorption and transfer into breast milk unlikely; no harmonised CLP flags or SCCS/CIR contraindications were identified (ECHA Annex VI, PubChem, CosIng).
Is poloxamer 182 safe for baby skin?
Hazard and mechanism: no evidence of developmental or reproductive hazard specific to infants. Exposure: because infant skin has a less mature barrier and higher surface-area-to-weight, dermal absorption potential is considered slightly higher than adults for ingredients that are not completely non-absorbable, so exposure score is increased by +1 (adult e=0 → infant e=1).
How does VeriMom score poloxamer 182?
VeriMom scores poloxamer 182 at 100/100 (no known risks) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
What are pregnancy-safe alternatives to poloxamer 182?
See our curated list of pregnancy-safe alternatives to poloxamer 182 based on similar function and a no-known-risks safety band.

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Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.

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