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Is poloxamer 124 safe during pregnancy?

Reviewed by · Last reviewed

Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
poloxamer 124
NO KNOWN RISKS
100
/100
0

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Frequently asked questions

Is poloxamer 124 safe during pregnancy?
The Cosmetic Ingredient Review (CIR) safety assessment (2008) evaluated many poloxamers including Poloxamer 124 and found no reproductive or developmental data but concluded 'safe as used' based on low skin penetration (high molecular weight, water‑soluble polymer) and rapid clearance when administered by other routes; no harmonised CLP classification for reproductive toxicity was found on ECHA. Therefore no reproductive hazard is identified. (CIR; ECHA substance info).
Is poloxamer 124 safe while breastfeeding?
No evidence of reproductive or developmental toxicity or mechanism suggesting transfer into breastmilk was identified in authoritative reviews. Poloxamers are large EO/PO block copolymers with minimal dermal absorption per the CIR assessment, so breastfeeding hazard is not indicated in available data (CIR; ECHA).
Is poloxamer 124 safe for baby skin?
Hazard and mechanism remain unsupported by data. Exposure score increased to 1 for infants (0–3 yr) because although adult dermal absorption is considered negligible/very low (CIR), infant skin has a higher surface‑area‑to‑weight ratio and immature barrier — so a small, measurable increase in exposure is plausible even if no toxicity is reported. No infant‑specific reproductive or developmental adverse findings were located.
How does VeriMom score poloxamer 124?
VeriMom scores poloxamer 124 at 100/100 (no known risks) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
What are pregnancy-safe alternatives to poloxamer 124?
See our curated list of pregnancy-safe alternatives to poloxamer 124 based on similar function and a no-known-risks safety band.

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Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.

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