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Is methylisothiazolinone safe during pregnancy?

No harmonised reproductive classification (no H360/H361) in ECHA Annex VI for methylisothiazolinone; authoritative assessments (ECHA Annex VI; CIR/SCCS coverage of isothiazolinones) identify acute toxicity and strong skin sensitization but do not identify developmental or reproductive toxicity. Dermal exposure from cosmetics is low but measurable for topical use (so e=1). Sources: ECHA Annex VI (harmonised CLP entries for isothiazolinones), CIR/SCCS reviews noting sensitization and local effects rather than reproductive hazards.

Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
methylisothiazolinone
NO KNOWN RISKS
93
/100
0

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Frequently asked questions

Is methylisothiazolinone safe during pregnancy?
No harmonised reproductive classification (no H360/H361) in ECHA Annex VI for methylisothiazolinone; authoritative assessments (ECHA Annex VI; CIR/SCCS coverage of isothiazolinones) identify acute toxicity and strong skin sensitization but do not identify developmental or reproductive toxicity. Dermal exposure from cosmetics is low but measurable for topical use (so e=1). Sources: ECHA Annex VI (harmonised CLP entries for isothiazolinones), CIR/SCCS reviews noting sensitization and local effects rather than reproductive hazards.
Is methylisothiazolinone safe while breastfeeding?
No evidence or harmonised classification indicating reproductive or lactation-specific toxicity or transfer to breastmilk; mechanism for reproductive/adverse developmental effects not reported. Systemic absorption from topical use can occur at low levels, so measurable but low exposure during breastfeeding (e=1). Sources: ECHA Annex VI; CIR/SCCS assessments; PubChem/GHS summaries.
Is methylisothiazolinone safe for baby skin?
No data indicating direct reproductive toxicity to infants or infant-specific mechanistic effects. However, methylisothiazolinone is a known potent skin sensitizer and can cause allergic contact dermatitis in infants; because infant skin has higher permeability and higher surface-area-to-weight, exposure ranking is increased by +1 (adult e=1 → infant e=2). This reflects higher potential for systemic uptake relative to adult use but not evidence of developmental toxicity. Sources: ECHA Annex VI (harmonised hazard classification including H317 skin sensitiser), CIR/SCCS commentary on isothiazolinone sensitization risk.
How does VeriMom score methylisothiazolinone?
VeriMom scores methylisothiazolinone at 93/100 (no known risks) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
What are pregnancy-safe alternatives to methylisothiazolinone?
See our curated list of pregnancy-safe alternatives to methylisothiazolinone based on similar function and a no-known-risks safety band.

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Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.

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