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Is isosorbide safe during pregnancy?

Reviewed by · Last reviewed

Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
isosorbide
NO KNOWN RISKS
93
/100
0

Pregnancy-safe products containing isosorbide

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Authoritative references used to score this ingredient.

Frequently asked questions

Is isosorbide safe during pregnancy?
No harmonised CLP reproductive classification or SCCS/CIR reproductive restriction found (ECHA Annex VI; CIR absent). PubChem and ECHA registration dossiers report no reproductive or developmental hazard data indicating teratogenicity; available toxicology indicates low systemic toxicity, so default hazard = 0. Dermal absorption is plausible but limited for this small, hydrophilic diol, so exposure from topical use is low but measurable (PubChem; ECHA dossiers).
Is isosorbide safe while breastfeeding?
No evidence of reproductive or developmental effects or endocrine activity in authoritative sources (ECHA dossiers; PubChem). Given low systemic exposure expected from topical use, transfer into breast milk is unlikely but measurable exposure cannot be excluded, therefore exposure score = 1.
Is isosorbide safe for baby skin?
No data indicating developmental/infant-specific toxicity (PubMed/ECHA). Because infant skin has higher permeability and surface-area-to-weight, increase exposure by +1 from adult (adult e=1 → infant e=2) though no specific infant absorption or toxicity data were found.
How does VeriMom score isosorbide?
VeriMom scores isosorbide at 93/100 (no known risks) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
What are pregnancy-safe alternatives to isosorbide?
See our curated list of pregnancy-safe alternatives to isosorbide based on similar function and a no-known-risks safety band.

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Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.

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