Is hydroxyproline safe during pregnancy?
Reviewed by VeriMom Editorial Team · Last reviewed
Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
hydroxyproline
NO KNOWN RISKS100
/100
0









Pregnancy-safe products containing hydroxyproline

Char's Effectives!
Char's Effectives! Snow Mushroom Serum For Normal To Very Dry Skin
98/100

Brillare Science
Brillare Science Heavy Moisturising Shampoo
98/100

Veganis
Veganis Serum Facial Luminosidad Profunda
98/100

The Mom's Co.
The Mom's Co. Natural Vita Rich Face Wash
98/100

NCN PRO SKINCARE
NCN PRO SKINCARE All-In-One Anti Aging Cream
98/100

Alula Skin
Alula Skin Vitamin C Serum
98/100

Testament
Testament Damascena Rose De-stress Moisturizer
97/100

AMWAY
Amway Attitude Be Bright Herbals Night Cream
97/100

Libra Cosmetica
Libra Cosmetica Loción Hidratante
97/100

Face facts
Face facts The Glow Routine Peptide Eye Gel Cream
97/100
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Authoritative references used to score this ingredient.
Frequently asked questions
- Is hydroxyproline safe during pregnancy?
- No harmonised CLP reproductive classification or SCCS/CIR reproductive safety restriction was found for hydroxyproline (CAS 51-35-4); it is a naturally occurring amino acid and component of collagen, and available regulatory records show CLP notifications for irritation endpoints only. No peer-reviewed human or animal studies reporting developmental/teratogenic effects from topical hydroxyproline were identified in searched literature. (ECHA brief profile; PubChem; CIR hydrolyzed collagen summary).
- Is hydroxyproline safe while breastfeeding?
- No data were found indicating hydroxyproline causes reproductive or lactation-specific toxicity, nor any classification (H360/H361) relevant to lactation. Hydroxyproline is a small, water‑soluble amino acid associated with collagen metabolism; regulatory dossiers and ingredient databases do not flag breastfeeding hazards. (ECHA brief profile; PubChem).
- Is hydroxyproline safe for baby skin?
- Hazard and mechanism evidence for reproductive or developmental toxicity is absent (h=0,m=0). Exposure (e) assigned 1 for baby skin because hydroxyproline is water‑soluble and not completely non‑absorbable; immature infant skin has higher permeability so a small but measurable dermal uptake is plausible for low‑molecular‑weight amino acids. There is no infant‑specific toxicology showing increased hazard. (PubChem; CIR hydrolyzed collagen; general dermal permeability rationale).
- How does VeriMom score hydroxyproline?
- VeriMom scores hydroxyproline at 100/100 (no known risks) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to hydroxyproline?
- See our curated list of pregnancy-safe alternatives to hydroxyproline based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.