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Is hydroxyproline safe during pregnancy?

Reviewed by · Last reviewed

Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
hydroxyproline
NO KNOWN RISKS
100
/100
0

Pregnancy-safe products containing hydroxyproline

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Authoritative references used to score this ingredient.

Frequently asked questions

Is hydroxyproline safe during pregnancy?
No harmonised CLP reproductive classification or SCCS/CIR reproductive safety restriction was found for hydroxyproline (CAS 51-35-4); it is a naturally occurring amino acid and component of collagen, and available regulatory records show CLP notifications for irritation endpoints only. No peer-reviewed human or animal studies reporting developmental/teratogenic effects from topical hydroxyproline were identified in searched literature. (ECHA brief profile; PubChem; CIR hydrolyzed collagen summary).
Is hydroxyproline safe while breastfeeding?
No data were found indicating hydroxyproline causes reproductive or lactation-specific toxicity, nor any classification (H360/H361) relevant to lactation. Hydroxyproline is a small, water‑soluble amino acid associated with collagen metabolism; regulatory dossiers and ingredient databases do not flag breastfeeding hazards. (ECHA brief profile; PubChem).
Is hydroxyproline safe for baby skin?
Hazard and mechanism evidence for reproductive or developmental toxicity is absent (h=0,m=0). Exposure (e) assigned 1 for baby skin because hydroxyproline is water‑soluble and not completely non‑absorbable; immature infant skin has higher permeability so a small but measurable dermal uptake is plausible for low‑molecular‑weight amino acids. There is no infant‑specific toxicology showing increased hazard. (PubChem; CIR hydrolyzed collagen; general dermal permeability rationale).
How does VeriMom score hydroxyproline?
VeriMom scores hydroxyproline at 100/100 (no known risks) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
What are pregnancy-safe alternatives to hydroxyproline?
See our curated list of pregnancy-safe alternatives to hydroxyproline based on similar function and a no-known-risks safety band.

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Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.

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