Is humulus lupulus extract safe during pregnancy?

Pregnancy-Safe Alternatives to humulus lupulus extract | VeriMom

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See also

• Is humulus lupulus extract safe for babies?
• What are pregnancy-safe alternatives to humulus lupulus extract?

Frequently asked questions

Is humulus lupulus extract safe during pregnancy?

Humulus lupulus (hops) extracts contain prenylflavonoids (notably 8‑prenylnaringenin, 8‑PN) with demonstrated estrogenic activity in vitro and in animal models; this supports a class-based reproductive concern but there is no EU Annex II/III restriction or harmonised reproductive classification. (CIR safety review; identification of 8‑PN).

Is humulus lupulus extract safe while breastfeeding?

Same mechanistic concern (phytoestrogenic constituents such as 8‑PN) applies; however, there is no evidence of harmonised classification or explicit contraindication for topical cosmetic use during lactation. Systemic transfer via breastmilk is theoretically possible if maternal systemic exposure is significant, but typical topical cosmetic exposure is low. (CIR; animal/human data on hop prenylflavonoids).

Is humulus lupulus extract safe for baby skin?

Hazard and mechanism mirror adult concerns (presence of estrogenic prenylflavonoids). Exposure score for infants increased because immature skin barrier and higher surface-area-to-weight make percutaneous absorption more likely even when adult topical absorption is low; no infant‑specific adverse data were located. (CIR; PubMed reviews on hop prenylflavonoids).

How does VeriMom score humulus lupulus extract?

VeriMom scores humulus lupulus extract at 60/100 (medium risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.

What are pregnancy-safe alternatives to humulus lupulus extract?

See our curated list of pregnancy-safe alternatives to humulus lupulus extract based on similar function and a no-known-risks safety band.