Безопасен ли glycyrrhetinic acid при беременности?

Безопасные альтернативы glycyrrhetinic acid при беременности | VeriMom

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Безопасен ли glycyrrhetinic acid при беременности?

Glycyrrhetinic acid is not listed in EU Annex II/III nor has a harmonised reproductive classification, but multiple human and mechanistic studies show it inhibits placental 11β‑HSD2 and maternal licorice (glycyrrhizin → glycyrrhetinic acid) intake is associated with adverse fetal/neurodevelopmental outcomes — supporting a 'suspected' reproductive hazard. ([echa.europa.eu](https://echa.europa.eu/substance-information/-/substanceinfo/100.006.769?utm_source=openai))

Безопасен ли glycyrrhetinic acid при грудном вскармливании?

No harmonised CLP reproductive/teratogenic classification was found; however the demonstrated mechanism (11β‑HSD2 inhibition) is relevant to glucocorticoid exposure. Systemic transfer to breastmilk after topical use is expected to be low but measurable if significant percutaneous absorption occurs. ([echa.europa.eu](https://echa.europa.eu/substance-information/-/substanceinfo/100.006.769?utm_source=openai))

Безопасен ли glycyrrhetinic acid для кожи малыша?

There is no infant‑specific evidence of teratogenicity from topical use, but because glycyrrhetinic acid has demonstrated biological activity (11β‑HSD2 inhibition) and infant skin has higher absorption per kg, exposure score is increased for 0–3 yr. No EU ban/restriction was identified for topical cosmetic use. ([echa.europa.eu](https://echa.europa.eu/substance-information/-/substanceinfo/100.006.769?utm_source=openai))

Как VeriMom оценивает glycyrrhetinic acid?

VeriMom оценивает glycyrrhetinic acid в 40/100 (средний риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы glycyrrhetinic acid при беременности?

См. наш список безопасных альтернатив glycyrrhetinic acid с аналогичной функцией и классификацией без известных рисков.