VeriMomIs glycyrrhetinic acid safe during pregnancy?
Reviewed by VeriMom Editorial Team · Last reviewed
Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
glycyrrhetinic acid
MEDIUM RISK40
/100
0
Pregnancy-Safe Alternatives to glycyrrhetinic acid | VeriMom
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Frequently asked questions
- Is glycyrrhetinic acid safe during pregnancy?
- Glycyrrhetinic acid is not listed in EU Annex II/III nor has a harmonised reproductive classification, but multiple human and mechanistic studies show it inhibits placental 11β‑HSD2 and maternal licorice (glycyrrhizin → glycyrrhetinic acid) intake is associated with adverse fetal/neurodevelopmental outcomes — supporting a 'suspected' reproductive hazard. ([echa.europa.eu](https://echa.europa.eu/substance-information/-/substanceinfo/100.006.769?utm_source=openai))
- Is glycyrrhetinic acid safe while breastfeeding?
- No harmonised CLP reproductive/teratogenic classification was found; however the demonstrated mechanism (11β‑HSD2 inhibition) is relevant to glucocorticoid exposure. Systemic transfer to breastmilk after topical use is expected to be low but measurable if significant percutaneous absorption occurs. ([echa.europa.eu](https://echa.europa.eu/substance-information/-/substanceinfo/100.006.769?utm_source=openai))
- Is glycyrrhetinic acid safe for baby skin?
- There is no infant‑specific evidence of teratogenicity from topical use, but because glycyrrhetinic acid has demonstrated biological activity (11β‑HSD2 inhibition) and infant skin has higher absorption per kg, exposure score is increased for 0–3 yr. No EU ban/restriction was identified for topical cosmetic use. ([echa.europa.eu](https://echa.europa.eu/substance-information/-/substanceinfo/100.006.769?utm_source=openai))
- How does VeriMom score glycyrrhetinic acid?
- VeriMom scores glycyrrhetinic acid at 40/100 (medium risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to glycyrrhetinic acid?
- See our curated list of pregnancy-safe alternatives to glycyrrhetinic acid based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.