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Is citrulline safe during pregnancy?

Reviewed by · Last reviewed

Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
citrulline
NO KNOWN RISKS
100
/100
0

Pregnancy-safe products containing citrulline

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Authoritative references used to score this ingredient.

Frequently asked questions

Is citrulline safe during pregnancy?
No harmonised CLP classification or SCCS/CIR safety assessment was found for citrulline (CAS 372-75-8). Clinical/peer‑reviewed literature reports on L‑citrulline focus on oral supplementation (e.g., vascular benefits in pregnancy animal models), not developmental toxicity from topical use, and do not indicate teratogenicity. Sources: PubMed study on pregnancy (animal, oral) and chemical databases showing no reproductive hazard classification. (PubMed; PubChem).
Is citrulline safe while breastfeeding?
No evidence of reproductive or lactation-specific toxicity from topical citrulline was identified in authoritative databases or in the peer‑review literature; available studies concern oral supplementation and report physiological effects via arginine/NO metabolism rather than reproductive harm. No regulatory breastfeeding warnings or harmonised classification were found. (PubMed; PubChem).
Is citrulline safe for baby skin?
Hazard and mechanism evidence for reproductive/ developmental toxicity are absent; however citrulline is a small, water‑soluble amino acid with measurable (but low) potential for dermal absorption—infant skin has higher relative uptake, so exposure score is increased by +1 for babies (0–3 yr) despite no hazard evidence. Cosmetic database listings (CosIng/SpecialChem) and EWG indicate use in topical products but no restriction. (Cosmetic ingredient listings; EWG; PubChem).
How does VeriMom score citrulline?
VeriMom scores citrulline at 100/100 (no known risks) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
What are pregnancy-safe alternatives to citrulline?
See our curated list of pregnancy-safe alternatives to citrulline based on similar function and a no-known-risks safety band.

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Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.

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