Is ammonium glycyrrhizate safe during pregnancy?

Pregnancy-Safe Alternatives to ammonium glycyrrhizate | VeriMom

Related ingredients

See also

• Is ammonium glycyrrhizate safe for babies?
• What are pregnancy-safe alternatives to ammonium glycyrrhizate?

Frequently asked questions

Is ammonium glycyrrhizate safe during pregnancy?

CIR’s final safety assessment includes ammonium glycyrrhizate and judges cosmetic use acceptable with typical use conditions, but independent human/epidemiological and toxicology assessments link glycyrrhizic/glycyrrhetinic acids (parent compounds) with pregnancy outcomes after oral exposure via inhibition of placental 11β‑HSD2 and associated fetal effects; therefore reproductive concern is suspected (h=2) with a demonstrated mechanism (m=2). For topical cosmetic use systemic absorption is expected to be low but measurable, so exposure score is 1. (Sources: CIR final report; VKM risk assessment; PBPK and human studies summarized in LactMed and literature).

Is ammonium glycyrrhizate safe while breastfeeding?

Glycyrrhizic acid (parent) has been detected in breastmilk after maternal oral intake and systemic effects are reported with ingestion; mechanism (11β‑HSD2 inhibition and systemic glycyrrhetinic metabolites) is demonstrated. For topical cosmetic use transfer to milk from topical use is unlikely but possible at low measurable levels, so exposure =1 and hazard =2 pending significant systemic exposure. (Sources: LactMed/NCBI; CIR; VKM).

Is ammonium glycyrrhizate safe for baby skin?

No infant‑specific topical hazard data found; hazard and mechanism remain linked to the parent glycyrrhizic/glycyrrhetinic acids (h=2, m=2). Because infant skin has higher per‑kg absorption, raise exposure by +1 compared with adults (adult e=1 → infant e=2) when the ingredient shows measurable absorption. No evidence supports increasing hazard or mechanism scores for infants in the absence of infant‑specific toxicology. (Sources: CIR; VKM; LactMed).

How does VeriMom score ammonium glycyrrhizate?

VeriMom scores ammonium glycyrrhizate at 40/100 (medium risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.

What are pregnancy-safe alternatives to ammonium glycyrrhizate?

See our curated list of pregnancy-safe alternatives to ammonium glycyrrhizate based on similar function and a no-known-risks safety band.