Безопасен ли punica granatum fruit/root/stem powder при беременности?
No harmonised CLP reproductive classification (ECHA Annex VI) or CIR/SCCS determination naming reproductive hazard for Punica granatum powder; therefore default hazard = 0. Some peer‑reviewed in vitro studies report estrogenic/ER-modulating activity for pomegranate extracts (PubMed), which is a theoretical mechanism only and does not demonstrate in vivo reproductive harm at cosmetic exposures, so m = 1. Topical cosmetic use of a botanical powder is expected to produce low but measurable dermal exposure (e = 1). Sources reviewed: ECHA Annex VI (no harmonised CLP), PubMed literature on pomegranate extracts, PubChem/CosIng entries.
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Frequently asked questions
- Безопасен ли punica granatum fruit/root/stem powder при беременности?
- No harmonised CLP reproductive classification (ECHA Annex VI) or CIR/SCCS determination naming reproductive hazard for Punica granatum powder; therefore default hazard = 0. Some peer‑reviewed in vitro studies report estrogenic/ER-modulating activity for pomegranate extracts (PubMed), which is a theoretical mechanism only and does not demonstrate in vivo reproductive harm at cosmetic exposures, so m = 1. Topical cosmetic use of a botanical powder is expected to produce low but measurable dermal exposure (e = 1). Sources reviewed: ECHA Annex VI (no harmonised CLP), PubMed literature on pomegranate extracts, PubChem/CosIng entries.
- Безопасен ли punica granatum fruit/root/stem powder при грудном вскармливании?
- As for pregnancy: no regulatory reproductive flags (ECHA Annex VI/SCCS/CIR) and no clinical evidence of harm during lactation; theoretical endocrine activity in vitro gives m = 1. Dermal exposure from cosmetics is low but measurable (e = 1); no data showing transfer into breastmilk.
- Безопасен ли punica granatum fruit/root/stem powder для кожи малыша?
- Hazard remains 0 (no harmonised classification or in vivo reproductive/tox studies indicating developmental/teratogenic effects). Mechanistic concern limited to in vitro estrogenic signals (m = 1) — no infant-specific mechanistic data. Exposure is increased for 0–3 yr due to immature barrier and higher surface-area-to-weight; therefore e is raised by +1 to 2 versus adult exposure.
- Как VeriMom оценивает punica granatum fruit/root/stem powder?
- VeriMom оценивает punica granatum fruit/root/stem powder в 87/100 (низкий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы punica granatum fruit/root/stem powder при беременности?
- См. наш список безопасных альтернатив punica granatum fruit/root/stem powder с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.