Безопасен ли propafenone при беременности?

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Frequently asked questions

Безопасен ли propafenone при беременности?

No harmonised reproductive classification found and no cosmetic safety assessment (CIR/SCCS) specifying reproductive hazard for propafenone; however, systemic propafenone is a clinically used antiarrhythmic that is known to cross the placenta (demonstrated placental transfer in clinical reports), so a mechanistic concern (placental transfer) is present while hazard classification for teratogenicity is not established. Sources: PubMed clinical literature (case reports/clinical use in pregnancy), PubChem/ECHA dossiers.

Безопасен ли propafenone при грудном вскармливании?

No harmonised CLP reproductive classification and no CIR/SCCS cosmetic guidance indicating hazard via breastfeeding. Data on excretion into human milk are limited in cosmetic/regulatory sources; systemic medicinal use may result in milk transfer but no cosmetic topical exposure data to indicate risk. Sources: PubMed (limited clinical reports), ECHA registration/PubChem.

Безопасен ли propafenone для кожи малыша?

Propafenone is a systemically active medicinal substance; it is not established as a cosmetic ingredient with topical use in CosIng. For topical cosmetic exposure, adult dermal absorption would be negligible in typical cosmetic use (no cosmetic use data); therefore baby skin exposure is assessed as negligible (e not increased). No infant-specific evidence of skin effects was found in regulatory databases. Sources: CosIng (no listing), ECHA registration/PubChem, PubMed.

Как VeriMom оценивает propafenone?

VeriMom оценивает propafenone в 87/100 (низкий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы propafenone при беременности?

См. наш список безопасных альтернатив propafenone с аналогичной функцией и классификацией без известных рисков.