Безопасен ли cucurbitacin b при беременности?

Безопасные альтернативы cucurbitacin b при беременности | VeriMom

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Безопасен ли cucurbitacin b при беременности?

No EU Annex II/III listing or harmonised CLP (no H360/H361 found). Peer‑reviewed studies show biologic activity and developmental effects in invertebrates (Drosophila) and multiple cytotoxic/anti‑proliferative effects in mammalian cell and cancer models, but I found no mammalian reproductive/developmental teratology studies showing fetal malformation in rodents or a harmonised reproductive classification — so classify as a structural/class concern (triterpenoid cytotoxin) rather than confirmed reproductive toxicant. Key sources: PubMed Drosophila developmental study and reviews showing potent bioactivity/cytotoxicity.

Безопасен ли cucurbitacin b при грудном вскармливании?

Same basis as pregnancy: biological activity and cytotoxicity in vitro and in vivo cancer models raise a plausible concern for systemic effects if absorbed, but there is no direct evidence of transfer into human milk or documented nursing-infant adverse outcomes. No harmonised CMR classification found to elevate hazard to h≥2.

Безопасен ли cucurbitacin b для кожи малыша?

No infant‑specific toxicity data. Because cucurbitacin B is a biologically active, low‑molecular‑weight triterpenoid with demonstrated cellular toxicity, assign a class/structural concern (h=1). Dermal absorption data are lacking; immature infant skin increases exposure potential so exposure score is increased (+1) to e=2 for 0–3 yr old skin. No infant dermal irritation/systemic developmental studies were found.

Как VeriMom оценивает cucurbitacin b?

VeriMom оценивает cucurbitacin b в 67/100 (средний риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы cucurbitacin b при беременности?

См. наш список безопасных альтернатив cucurbitacin b с аналогичной функцией и классификацией без известных рисков.