VeriMomСтоит ли избегать trimethyl pentanyl diisobutyrate при беременности? | VeriMom
Trimethyl pentanyl diisobutyrate (TXIB; CAS 6846-50-0) has a harmonised/suspected reproductive hazard classification (H361) in regulatory sources and registration dossiers reporting reduced implant numbers and reduced litter weights in an OECD 421 rat study, supporting a suspected reproductive hazard. (ECHA registration dossier and SDS reporting H361; see sources). In vitro and ex vivo studies (fetal testis organ culture; gonadal cell lines) show biologically plausible effects on reproductive endpoints/sex-hormone related parameters, indicating a demonstrated mechanistic signal. Topical cosmetic exposure would generally give low but measurable systemic exposure (so e=1) for pregnant adults absent product-specific dermal absorption data.
ECHA regulatory hazard statements
- •H361
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли trimethyl pentanyl diisobutyrate при беременности?
- Trimethyl pentanyl diisobutyrate (TXIB; CAS 6846-50-0) has a harmonised/suspected reproductive hazard classification (H361) in regulatory sources and registration dossiers reporting reduced implant numbers and reduced litter weights in an OECD 421 rat study, supporting a suspected reproductive hazard. (ECHA registration dossier and SDS reporting H361; see sources). In vitro and ex vivo studies (fetal testis organ culture; gonadal cell lines) show biologically plausible effects on reproductive endpoints/sex-hormone related parameters, indicating a demonstrated mechanistic signal. Topical cosmetic exposure would generally give low but measurable systemic exposure (so e=1) for pregnant adults absent product-specific dermal absorption data.
- Безопасен ли trimethyl pentanyl diisobutyrate при грудном вскармливании?
- Same hazard basis applies (harmonised H361 / OECD 421 reproductive findings). Mechanistic data (in vitro/ex vivo endocrine-related effects and interactions with sex-hormone binding protein) support potential for reproductive/endocrine activity. With typical topical cosmetic use, maternal systemic exposure is expected to be low but measurable; specific data on transfer into human milk are not available, so exposure is scored as low (e=1).
- Безопасен ли trimethyl pentanyl diisobutyrate для кожи малыша?
- Hazard and mechanistic evidence remain the same (H361; animal reproductive/developmental signals; in vitro/ex vivo endocrine-related findings). Infant skin has higher absorption per kg, so exposure score is increased by +1 versus adults (adult e=1 → baby e=2) in the absence of definitive dermal absorption data for cosmetic formulations intended for infants.
- Как VeriMom оценивает trimethyl pentanyl diisobutyrate?
- VeriMom оценивает trimethyl pentanyl diisobutyrate в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы trimethyl pentanyl diisobutyrate при беременности?
- См. наш список безопасных альтернатив trimethyl pentanyl diisobutyrate с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.