Стоит ли избегать tazarotene при беременности? | VeriMom

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли tazarotene при беременности?

Strong evidence of teratogenicity from animal studies and long-standing regulatory warnings (FDA labeling/former Category X). Tazarotene is a topical retinoid that is a prodrug for a retinoic acid receptor agonist (well‑characterized mechanism mediating developmental toxicity). Systemic absorption after topical use is low but measurable, so fetal exposure cannot be excluded. Sources: FDA prescribing information and peer‑reviewed reviews summarizing animal teratology and labeling. (See sources.)

Безопасен ли tazarotene при грудном вскармливании?

Animal data show transfer of radioactivity into milk after topical dosing and plausible transfer of drug‑related material via milk; mechanism (retinoid activity) is relevant and transfer documented in animals, so hazard is suspected. Systemic levels after topical use are low but measurable; human milk transfer data are limited. (See sources.)

Безопасен ли tazarotene для кожи малыша?

Direct application to infant skin is not appropriate given retinoid pharmacology and developmental activity (mechanism: RAR agonism). If exposure is via contact with treated caregiver skin, infant exposure risk is higher than adult due to immature barrier and higher surface‑area‑to‑weight; animal data show milk transfer. No infant‑specific safety data support direct use. Exposure score increased +1 relative to adult because infant skin is more permissive. (See sources.)

Как VeriMom оценивает tazarotene?

VeriMom оценивает tazarotene в 13/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы tazarotene при беременности?

См. наш список безопасных альтернатив tazarotene с аналогичной функцией и классификацией без известных рисков.