VeriMomСтоит ли избегать retinyl retinoate при беременности? | VeriMom
No harmonised ECHA H360 classification or specific reproductive/teratology studies were located for retinyl retinoate itself, so a confirmed H360-level hazard cannot be assigned; however it is a retinoid ester that can produce retinoid activity and retinoic-acid-mediated developmental effects are well‑characterised, so a class-based theoretical reproductive concern is justified (h=1). The mechanism is well‑characterised as retinoic acid receptor agonism and metabolic conversion to active retinoid species in skin (m=3). Topical absorption is low but measurable for retinyl esters per SCCS (exposure order: retinyl esters << retinol < retinal < retinoic acid), so adult topical exposure is scored low but measurable (e=1).
ECHA regulatory hazard statements
- •H360
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли retinyl retinoate при беременности?
- No harmonised ECHA H360 classification or specific reproductive/teratology studies were located for retinyl retinoate itself, so a confirmed H360-level hazard cannot be assigned; however it is a retinoid ester that can produce retinoid activity and retinoic-acid-mediated developmental effects are well‑characterised, so a class-based theoretical reproductive concern is justified (h=1). The mechanism is well‑characterised as retinoic acid receptor agonism and metabolic conversion to active retinoid species in skin (m=3). Topical absorption is low but measurable for retinyl esters per SCCS (exposure order: retinyl esters << retinol < retinal < retinoic acid), so adult topical exposure is scored low but measurable (e=1).
- Безопасен ли retinyl retinoate при грудном вскармливании?
- No direct data on transfer of retinyl retinoate into human milk were found. By analogy to other topical retinoid esters and because retinoids have a known receptor‑mediated mechanism, a theoretical class-based concern for nursing infants applies (h=1) and the mechanism remains retinoid receptor activity (m=3). Systemic exposure from typical topical cosmetic use is expected to be low but measurable, so exposure via maternal use during breastfeeding is scored low (e=1).
- Безопасен ли retinyl retinoate для кожи малыша?
- No infant-specific toxicology studies for retinyl retinoate were found. Hazard remains a class-based theoretical retinoid concern (h=1) with the same retinoid receptor mechanism (m=3). Because infant skin (0–3 yr) has higher surface-area-to-weight and an immature barrier, exposure score is increased by +1 from adult topical use (adult e=1 → baby e=2) when measurable dermal absorption exists. Note: SCCS has evaluated retinol and common retinyl esters and recommends concentration limits/warnings; retinoic acid itself is banned in cosmetics (SCCS).
- Как VeriMom оценивает retinyl retinoate?
- VeriMom оценивает retinyl retinoate в 13/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы retinyl retinoate при беременности?
- См. наш список безопасных альтернатив retinyl retinoate с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.