Стоит ли избегать propylene glycol dicaproate при беременности? | VeriMom
No harmonised Annex‑VI (H360/H361) entry could be confirmed on ECHA’s harmonised CLP lists; registration and supplier docs exist for propylene glycol dicaproate (50343-36-7) and some safety data sheets list H361 wording but these appear to be supplier/self-classifications rather than an EU harmonised classification. No peer‑reviewed reproductive or developmental studies were located. The compound is a lipophilic ester (estimated logP ≈ 4–4.6) so low but measurable dermal absorption is plausible for adults. Sources: ECHA registration page and PubChem entry; multiple supplier/SDS pages that list H361 wording (likely self-classifications).
ECHA regulatory hazard statements
- •H361
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли propylene glycol dicaproate при беременности?
- No harmonised Annex‑VI (H360/H361) entry could be confirmed on ECHA’s harmonised CLP lists; registration and supplier docs exist for propylene glycol dicaproate (50343-36-7) and some safety data sheets list H361 wording but these appear to be supplier/self-classifications rather than an EU harmonised classification. No peer‑reviewed reproductive or developmental studies were located. The compound is a lipophilic ester (estimated logP ≈ 4–4.6) so low but measurable dermal absorption is plausible for adults. Sources: ECHA registration page and PubChem entry; multiple supplier/SDS pages that list H361 wording (likely self-classifications).
- Безопасен ли propylene glycol dicaproate при грудном вскармливании?
- Same rationale as pregnancy: no confirmed harmonised classification or peer‑reviewed evidence of reproductive/developmental toxicity; limited data on mammary/transfer into milk. Low but measurable systemic exposure after topical use is plausible but not documented.
- Безопасен ли propylene glycol dicaproate для кожи малыша?
- No infant‑specific toxicology found. Per your scoring rules, exposure (e) is increased by +1 for 0–3 y because the substance shows plausible dermal absorption (lipophilic ester); therefore exposure for baby skin is scored as moderate. Hazard and mechanism scores remain based on available data (no direct repro mechanism or infant data).
- Как VeriMom оценивает propylene glycol dicaproate?
- VeriMom оценивает propylene glycol dicaproate в 33/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы propylene glycol dicaproate при беременности?
- См. наш список безопасных альтернатив propylene glycol dicaproate с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.