Стоит ли избегать pregnenolone acetate при беременности? | VeriMom

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Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли pregnenolone acetate при беременности?

Hazard: animal and mechanistic evidence that pregnenolone and related steroids modulate sex‑steroid signalling and can affect reproductive tissues (peer‑reviewed studies), and multiple supplier SDSs/self‑classifications list H361 (suspected of damaging fertility/unborn child). Mechanism: demonstrated steroid/estrogen receptor modulation and biological activity in animal models (pregnenolone effects on uterine ER expression and developmental effects in embryos). Exposure: topical cosmetic use historically (e.g., 1% creams) and the molecule is lipophilic so low but measurable dermal absorption is plausible for adults. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30411422/?utm_source=openai))

Безопасен ли pregnenolone acetate при грудном вскармливании?

Hazard & mechanism: because the acetate is converted to pregnenolone (a steroid precursor) and pregnenolone shows endocrine activity in animals, there is potential risk to the nursing infant if significant systemic maternal exposure occurs; mechanism (steroid activity and ability to alter hormone signalling) is demonstrated in animal studies. Exposure: dermal use by nursing mothers would likely give low but measurable maternal systemic exposure (therefore low infant exposure via breastmilk is plausible), but direct data on lactation transfer are lacking. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30411422/?utm_source=openai))

Безопасен ли pregnenolone acetate для кожи малыша?

Hazard & mechanism: same concerns as for pregnancy — conversion to an active steroid (pregnenolone) and demonstrated endocrine/reproductive effects in animal models justify a suspected hazard for infants. Exposure: infant (0–3 yr) skin has higher surface‑area‑to‑weight and less mature barrier; therefore dermal exposure potential is increased (+1 exposure score). Direct infant dermal safety data are not available. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30411422/?utm_source=openai))

Как VeriMom оценивает pregnenolone acetate?

VeriMom оценивает pregnenolone acetate в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы pregnenolone acetate при беременности?

См. наш список безопасных альтернатив pregnenolone acetate с аналогичной функцией и классификацией без известных рисков.