Стоит ли избегать plectranthus barbatus root extract при беременности? | VeriMom

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли plectranthus barbatus root extract при беременности?

No EU cosmetic ban/restriction was found for Plectranthus/Coleus (INCI listed in the EU Official Journal), but the root extract contains forskolin. Forskolin has been shown to induce endocrine disturbances in human placental JEG‑3 cells (in vitro) and an older rat study reported anti‑implantation/delayed fetal effects — therefore reproductive hazard is “suspected” (h=2) with a demonstrated mechanism (m=2). An in vitro skin diffusion study showed forskolin can permeate human skin and permeation is enhanced when delivered in the crude P. barbatus root extract, so topical exposure is measurable/moderate (e=2). Sources: EU CosIng/Official Journal; in vitro placental study (PMCID: PMC9317975); in vitro skin diffusion J Nat Prod (Chen et al.).

Безопасен ли plectranthus barbatus root extract при грудном вскармливании?

There are no reliable human milk/excretion studies for Plectranthus/forskolin; guidance resources warn against oral use in pregnancy/lactation due to limited safety data. Because systemic exposure to forskolin could theoretically affect nursing infants but direct evidence for adverse effects via breastmilk is lacking, assign a low/class‑based concern (h=1) with a theoretical mechanism (m=1). Topical cosmetic use has low but measurable systemic absorption potential (e=1). Sources: LactMed/NCBI Monograph; WebMD summary; PMC placental study (mechanistic relevance).

Безопасен ли plectranthus barbatus root extract для кожи малыша?

No infant‑specific adverse dermatologic or developmental data were found for topical Plectranthus barbatus root extract. Per instructions, baby hazard (h) and mechanism (m) were not increased in the absence of infant‑specific evidence. However, because the extract (and forskolin within it) shows measurable skin permeation in vitro and infant skin has higher surface‑area‑to‑weight and immature barrier, exposure is increased for babies (+1 vs adult), giving e=3. Sources: J Nat Prod skin diffusion study; no baby‑specific safety studies located.

Как VeriMom оценивает plectranthus barbatus root extract?

VeriMom оценивает plectranthus barbatus root extract в 33/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы plectranthus barbatus root extract при беременности?

См. наш список безопасных альтернатив plectranthus barbatus root extract с аналогичной функцией и классификацией без известных рисков.