Стоит ли избегать phenolphthalein при беременности? | VeriMom

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли phenolphthalein при беременности?

Phenolphthalein has harmonised CLP classifications for reproductive toxicity including H360 (per ECHA brief profile / Annex VI) and H361f (suspected of damaging fertility), which meets the criterion for H360-level evidence → h=3. There is experimental evidence of estrogenic activity/in vitro endocrine effects and genotoxicity in animal/in vitro studies supporting a demonstrated mechanism (m=2). For typical topical cosmetic use systemic absorption is likely low but measurable, so exposure is scored e=1. Sources: ECHA harmonised classification, NTP/animal carcinogenicity/genotoxicity literature, in vitro estrogenic reports.

Безопасен ли phenolphthalein при грудном вскармливании?

Harmonised classification includes reproductive concerns (H361f) and the substance has animal/genotoxic and in vitro estrogenic data; breastfeeding is scored h=2 because harmonised H361 (suspected reproductive hazard) supports 'suspected' rather than confirmed systemic teratogen for lactation exposure. Mechanistic data (in vitro estrogenic activity, genotoxicity) give m=2. Systemic absorption from topical use is likely low but measurable, so milk transfer risk is low but not negligible (e=1).

Безопасен ли phenolphthalein для кожи малыша?

For infant topical exposure (0–3 yr) the hazard score is maintained at h=2 (suspected reproductive/toxic effects per harmonised H361; H360-level evidence applies to developmental systemic teratogenesis but infant-skin–specific teratogenic data are not available so h is not escalated to 3). No infant‑specific mechanistic data identified, so m=0 (do not increase m without infant-specific evidence). Adult topical absorption judged low but measurable (adult e=1), and per instruction baby skin exposure is increased by +1 → e=2. Overall infant dermal exposure could be higher due to immature barrier and higher surface-area-to-weight ratio. Sources cited below.

Как VeriMom оценивает phenolphthalein?

VeriMom оценивает phenolphthalein в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы phenolphthalein при беременности?

См. наш список безопасных альтернатив phenolphthalein с аналогичной функцией и классификацией без известных рисков.