Стоит ли избегать nitrous oxide при беременности? | VeriMom

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли nitrous oxide при беременности?

Dinitrogen oxide (nitrous oxide, CAS 10024-97-2) now has a harmonised CLP classification in the EU as Repr. 1B (H360Df) (Official Journal / CLP Annex VI update), which by calibration requires h=3. The mechanistic literature shows demonstrated inactivation of methionine‑synthase / perturbation of folate‑B12 pathways in animals and human cells (PubMed), supporting m=2. For normal topical cosmetic use the expected topical dermal/systemic absorption from a finished cosmetic product is negligible, so exposure (e) for pregnancy from topical use is scored 0; however inhalation (medical or recreational) is a separate, high‑exposure route and is outside routine cosmetic topical exposure assumptions.

Безопасен ли nitrous oxide при грудном вскармливании?

Harmonised Repr.1B (H360Df) applies to the substance (h=3). Mechanism is the same as for pregnancy (methionine synthase / folate interference documented) so m=2. For typical cosmetic topical application breastfeeding exposure is expected to be negligible (e=0). Inhalation/medical exposure would increase exposure but is not typical for cosmetics.

Безопасен ли nitrous oxide для кожи малыша?

Hazard remains h=3 because of the harmonised Repr.1B classification. Mechanistic evidence (B12/methionine synthase inhibition, folate perturbation) supports m=2. For infant skin (0–3 yr) assume increased potential exposure relative to adults; since the substance is not completely non‑absorbable and infants have a less mature barrier the exposure score is increased by +1 (adult e=0 → infant e=1). Topical cosmetic use still would normally produce negligible systemic uptake, but infant susceptibility and increased surface‑area‑to‑weight justify the +1 increase.

Как VeriMom оценивает nitrous oxide?

VeriMom оценивает nitrous oxide в 27/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы nitrous oxide при беременности?

См. наш список безопасных альтернатив nitrous oxide с аналогичной функцией и классификацией без известных рисков.