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Стоит ли избегать nitrophenol при беременности? | VeriMom

No harmonised reproductive classification (H360/H361) for 2‑nitrophenol (CAS 88‑75‑5) was found in the ECHA harmonised CLP lists, and toxicological reviews (ATSDR summary, ECHA registration dossiers) do not identify reproductive/developmental toxicity as a target organ for nitrophenols; therefore no reproductive hazard is documented. Dermal toxicity data indicate relatively low dermal hazard (large LD50), so exposure from a cosmetic topical use would be low but potentially measurable. (Sources: ECHA registration dossier; ATSDR summary; Sigma Aldrich product data).

ECHA regulatory hazard statements

  • H361

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли nitrophenol при беременности?
No harmonised reproductive classification (H360/H361) for 2‑nitrophenol (CAS 88‑75‑5) was found in the ECHA harmonised CLP lists, and toxicological reviews (ATSDR summary, ECHA registration dossiers) do not identify reproductive/developmental toxicity as a target organ for nitrophenols; therefore no reproductive hazard is documented. Dermal toxicity data indicate relatively low dermal hazard (large LD50), so exposure from a cosmetic topical use would be low but potentially measurable. (Sources: ECHA registration dossier; ATSDR summary; Sigma Aldrich product data).
Безопасен ли nitrophenol при грудном вскармливании?
No data were found showing reproductive or lactation-specific toxicity or transfer in milk. No harmonised CLP reproductive hazard (H360/H361) applies. Given small molecular weight and limited dermal data, topical exposure would be low but measurable; breastfeeding-specific transfer data are absent. (Sources: ECHA registration dossier; ATSDR; Sigma Aldrich).
Безопасен ли nitrophenol для кожи малыша?
No infant-specific toxicity or developmental effects were identified in the sources reviewed. Absorption from skin is possible and infant skin has higher surface‑area‑to‑weight and immature barrier — therefore exposure rating is increased by one step for 0–3 yr old compared with adults (low → moderate). No evidence was found that 2‑nitrophenol is used in cosmetics or that it accumulates in skin. (Sources: ATSDR toxicological profile; ECHA registration dossier; product safety sheets).
Как VeriMom оценивает nitrophenol?
VeriMom оценивает nitrophenol в 33/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
Какие безопасные альтернативы nitrophenol при беременности?
См. наш список безопасных альтернатив nitrophenol с аналогичной функцией и классификацией без известных рисков.

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Медицинская оговорка

Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.

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