Стоит ли избегать nifedipine при беременности? | VeriMom

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Безопасные альтернативы nifedipine при беременности | VeriMom

Ингредиенты — Ингредиенты

См. также

• Безопасен ли nifedipine при беременности?
• Безопасен ли nifedipine для малышей?
• Какие безопасные при беременности альтернативы nifedipine?

FAQ

Безопасен ли nifedipine при беременности?

Nifedipine is a systemic pharmaceutical (a dihydropyridine Ca2+ channel blocker) with evidence of fetal exposure: PBPK and clinical studies report substantial transplacental transfer (cord:maternal ratios ≈ ~1 in modelling and clinical measurements), and supplier safety data sheets list reproductive toxicity H361 (suspected of damaging fertility or the unborn child). Because ECHA-harmonised H360 classification was not identified but H361 is reported in SDS/registrations, hazard is scored as 'suspected' (h=2); mechanism is 'demonstrated' (m=2) because placental transfer and pharmacodynamic effects on uteroplacental blood flow are reported; topical cosmetic exposure is likely low but systemic if used as a drug, so for cosmetic topical use exposure is low (e=1). (Sources: PBPK and placental studies, systematic reviews and SDSs.).

Безопасен ли nifedipine при грудном вскармливании?

Nifedipine is excreted into breastmilk in measurable but generally small amounts and is commonly considered compatible with breastfeeding in clinical guidance; supplier SDSs list reproductive toxicity H361 which supports a suspected reproductive hazard (h=2). Mechanistically, milk transfer is documented (so m=1–2), but adverse effects in infants are not robustly reported in the clinical literature; for topical cosmetic use exposure is expected to be low (e=1).

Безопасен ли nifedipine для кожи малыша?

There is no infant-specific dermal hazard data for 0–3 yr; nifedipine is systemically active and can cross placenta / enter milk, so parental systemic concern remains (h=2). For baby skin, because infants have higher skin absorption and the parent compound is moderately lipophilic (not completely non-absorbable), increase exposure score by +1 relative to adult topical use (adult e=1 → infant e=2). No direct evidence supports increasing hazard or mechanism beyond adult data in absence of infant-specific studies.

Как VeriMom оценивает nifedipine?

VeriMom оценивает nifedipine в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы nifedipine при беременности?

См. наш список безопасных альтернатив nifedipine с аналогичной функцией и классификацией без известных рисков.