VeriMomСтоит ли избегать methylene di-t-butylcresol при беременности? | VeriMom
ECHA lists 6,6'-di-tert‑butyl‑2,2'‑methylenedi‑p‑cresol (CAS 119‑47‑1) with a harmonised classification for reproductive toxicity (Repr. 1B, H360F — “May damage fertility”), which by the scoring rules yields h=3. Animal reproductive/developmental findings are reported in regulatory dossiers (developmental NOAEL/LOAEL in non‑rodents in EPA/registration material), but a specific molecular reproductive mechanism is not established in the literature (m=1). For routine topical cosmetic use dermal absorption is likely low but not zero (lipophilic high‑molecular phenolic antioxidant), so exposure for a pregnant adult is scored as low but measurable (e=1). Sources: ECHA harmonised classification and registration/assessment data and regulatory toxicology summaries.
ECHA regulatory hazard statements
- •H360F
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли methylene di-t-butylcresol при беременности?
- ECHA lists 6,6'-di-tert‑butyl‑2,2'‑methylenedi‑p‑cresol (CAS 119‑47‑1) with a harmonised classification for reproductive toxicity (Repr. 1B, H360F — “May damage fertility”), which by the scoring rules yields h=3. Animal reproductive/developmental findings are reported in regulatory dossiers (developmental NOAEL/LOAEL in non‑rodents in EPA/registration material), but a specific molecular reproductive mechanism is not established in the literature (m=1). For routine topical cosmetic use dermal absorption is likely low but not zero (lipophilic high‑molecular phenolic antioxidant), so exposure for a pregnant adult is scored as low but measurable (e=1). Sources: ECHA harmonised classification and registration/assessment data and regulatory toxicology summaries.
- Безопасен ли methylene di-t-butylcresol при грудном вскармливании?
- Same harmonised reproductive classification (Repr. 1B, H360F) applies and supports a high hazard score (h=3). No clear mechanistic data specific to lactational transfer was found (m=1). For topical cosmetic use, maternal dermal exposure is expected to be low but measurable; breastmilk transfer is plausible for lipophilic compounds but was not documented in available studies, so exposure is scored as low (e=1). Regulatory guidance therefore flags this substance for reproductive concern.
- Безопасен ли methylene di-t-butylcresol для кожи малыша?
- Hazard remains high because of the harmonised Repr.1B/H360F classification (h=3). No infant‑specific mechanism data was identified (m=1). Because infant skin (0–3 yr) has higher absorption per body weight and an immature barrier, exposure score is increased by +1 relative to adults (adult e=1 → baby e=2) where dermal absorption is measurable. No infant dermal studies were located to justify changing hazard or mechanism scores.
- Как VeriMom оценивает methylene di-t-butylcresol?
- VeriMom оценивает methylene di-t-butylcresol в 27/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы methylene di-t-butylcresol при беременности?
- См. наш список безопасных альтернатив methylene di-t-butylcresol с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.