VeriMomСтоит ли избегать isobutylparaben при беременности? | VeriMom
ECHA has listed isobutyl 4‑hydroxybenzoate (isobutylparaben) on the REACH Candidate List as an SVHC for toxic for reproduction (Article 57(c)) and for endocrine‑disrupting properties (Article 57(f)), indicating substantive regulatory concern for reproductive effects. Peer‑reviewed work shows estrogenic activity in vitro and in vivo for isobutylparaben (Darbre et al./Vo et al. type studies). The cosmetic industry/CIR historical assessment (2008) concluded parabens are safe 'as used', but more recent regulatory actions (EU prohibition) and the ECHA Candidate List indicate reproductive/ED hazard evidence warranting high hazard scoring.
ECHA regulatory hazard statements
- •H360
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли isobutylparaben при беременности?
- ECHA has listed isobutyl 4‑hydroxybenzoate (isobutylparaben) on the REACH Candidate List as an SVHC for toxic for reproduction (Article 57(c)) and for endocrine‑disrupting properties (Article 57(f)), indicating substantive regulatory concern for reproductive effects. Peer‑reviewed work shows estrogenic activity in vitro and in vivo for isobutylparaben (Darbre et al./Vo et al. type studies). The cosmetic industry/CIR historical assessment (2008) concluded parabens are safe 'as used', but more recent regulatory actions (EU prohibition) and the ECHA Candidate List indicate reproductive/ED hazard evidence warranting high hazard scoring.
- Безопасен ли isobutylparaben при грудном вскармливании?
- Because isobutylparaben is identified by ECHA as an SVHC for reproductive toxicity and endocrine disruption, and it has demonstrated estrogenic activity in experimental studies, it is reasonable to treat the reproductive/ED hazard as relevant to lactation. Measured systemic absorption from dermal application is low but measurable (CIR notes measurable penetration and rapid metabolism), so maternal systemic exposure (and potential transfer into milk) cannot be excluded.
- Безопасен ли isobutylparaben для кожи малыша?
- EU cosmetics regulation has removed isobutylparaben from allowed preservatives (placed in Annex II, prohibited). Infants have a higher surface‑area‑to‑body‑weight and immature metabolism; given measurable dermal penetration and the substance's SVHC listing for reproductive/ED properties, exposure for baby skin is scored higher (adult e increased by +1). Additionally, some EU/Member‑State actions specifically cited concern for infant exposures to certain parabens.
- Как VeriMom оценивает isobutylparaben?
- VeriMom оценивает isobutylparaben в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы isobutylparaben при беременности?
- См. наш список безопасных альтернатив isobutylparaben с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.