VeriMomСтоит ли избегать ibuprofen при беременности? | VeriMom
Ibuprofen (CAS 15687-27-1) is an NSAID with human/animal evidence of adverse fetal effects (fetal renal dysfunction/oligohydramnios and premature ductus arteriosus closure) prompting an FDA warning to avoid NSAID use at ≈20 weeks gestation and later; this supports a 'suspected' reproductive hazard (h=2). The mechanism is demonstrated (prostaglandin inhibition → fetal renal/ductus arteriosus effects), so m=2. Topical/cosmetic use yields low but measurable systemic exposure vs oral use, so exposure for topical cosmetic use is low (e=1). Sources: FDA, MotherToBaby/NCBI, ECHA substance information.
ECHA regulatory hazard statements
- •H360
- •H361
- •H362
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли ibuprofen при беременности?
- Ibuprofen (CAS 15687-27-1) is an NSAID with human/animal evidence of adverse fetal effects (fetal renal dysfunction/oligohydramnios and premature ductus arteriosus closure) prompting an FDA warning to avoid NSAID use at ≈20 weeks gestation and later; this supports a 'suspected' reproductive hazard (h=2). The mechanism is demonstrated (prostaglandin inhibition → fetal renal/ductus arteriosus effects), so m=2. Topical/cosmetic use yields low but measurable systemic exposure vs oral use, so exposure for topical cosmetic use is low (e=1). Sources: FDA, MotherToBaby/NCBI, ECHA substance information.
- Безопасен ли ibuprofen при грудном вскармливании?
- Available clinical guidance and reviews indicate very low transfer of ibuprofen into human milk and no documented infant harm for usual maternal doses; therefore no reproductive/breastfeeding hazard is indicated (h=0, m=0). Milk transfer is measurable but low, so e=1. Sources: MotherToBaby (NCBI), NHS Specialist Pharmacy Service; clinical references note ibuprofen is generally compatible with breastfeeding.
- Безопасен ли ibuprofen для кожи малыша?
- Hazard (h=2) is carried over because systemic reproductive/toxicity evidence for ibuprofen exists (see pregnancy summary). Per instructions, infant-specific hazard or mechanism were not found so h and m are not increased beyond adult evidence (m=2). Topical exposure for infants is increased relative to adults (immature barrier and higher surface-area-to-weight) so exposure is raised by +1 (adult e=1 → baby e=2). No infant-specific studies were found showing different hazard; precautionary higher exposure score applied.
- Как VeriMom оценивает ibuprofen?
- VeriMom оценивает ibuprofen в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы ibuprofen при беременности?
- См. наш список безопасных альтернатив ibuprofen с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.