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Стоит ли избегать dimethoxydiglycol при беременности? | VeriMom

Diethylene glycol dimethyl ether (CAS 111-96-6, aka diglyme / dimethoxydiglycol) has a harmonised CLP classification for reproductive toxicity H360 (may damage fertility or the unborn child) / H360FD reported by ECHA; animal studies report testicular and fetal toxicity (prenatal developmental toxicity / fetal effects). These support a confirmed reproductive hazard (h=3). Mechanistic data show demonstrated reproductive/developmental effects in animals (m=2). For topical cosmetic use systemic exposure is expected to be measurable (solvent with dermal absorption potential), so exposure scoring is moderate (e=2). Sources: ECHA substance / registration and published prenatal studies.

ECHA regulatory hazard statements

  • H360FD

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли dimethoxydiglycol при беременности?
Diethylene glycol dimethyl ether (CAS 111-96-6, aka diglyme / dimethoxydiglycol) has a harmonised CLP classification for reproductive toxicity H360 (may damage fertility or the unborn child) / H360FD reported by ECHA; animal studies report testicular and fetal toxicity (prenatal developmental toxicity / fetal effects). These support a confirmed reproductive hazard (h=3). Mechanistic data show demonstrated reproductive/developmental effects in animals (m=2). For topical cosmetic use systemic exposure is expected to be measurable (solvent with dermal absorption potential), so exposure scoring is moderate (e=2). Sources: ECHA substance / registration and published prenatal studies.
Безопасен ли dimethoxydiglycol при грудном вскармливании?
Harmonised CLP H360 indicates reproductive toxicity including effects on fertility and the unborn; animal data demonstrate systemic reproductive toxicity. Given systemic toxicity and documented capacity to cause reproductive effects after systemic exposure, breastfeeding is a concern because the chemical is bioavailable and could transfer to milk (exposure moderate for dermal use). No high-quality human lactation studies were found; conclusions rely on harmonised classification and animal data.
Безопасен ли dimethoxydiglycol для кожи малыша?
Hazard and mechanism scores follow the harmonised classification and animal reproductive data (h=3, m=2). Absorption/exposure is increased for infants (immature barrier and higher surface-area-to-weight); because adult topical use produces measurable systemic exposure (e=2), raise baby skin exposure by +1 → e=3. Therefore use on infant (0–3 yr) skin is of high concern.
Как VeriMom оценивает dimethoxydiglycol?
VeriMom оценивает dimethoxydiglycol в 13/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
Какие безопасные альтернативы dimethoxydiglycol при беременности?
См. наш список безопасных альтернатив dimethoxydiglycol с аналогичной функцией и классификацией без известных рисков.

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Медицинская оговорка

Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.

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