VeriMomСтоит ли избегать clotrimazole при беременности? | VeriMom
Clotrimazole is listed with a harmonised CLP classification of H361 (suspected of damaging fertility or the unborn child) on ECHA, which supports a ‘suspected’ reproductive hazard (h=2). A recent peer‑reviewed rat study showed that systemic exposure to clotrimazole altered maternal and fetal steroid hormone profiles via CYP/steroidogenesis inhibition (demonstrated mechanism → m=2). For typical topical/vaginal cosmetic/OTC use systemic absorption is minimal but measurable, so exposure from topical cosmetic use is rated low (e=1). Sources: ECHA harmonised classification and PubMed study, plus product labeling on animal effects.
ECHA regulatory hazard statements
- •H361
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли clotrimazole при беременности?
- Clotrimazole is listed with a harmonised CLP classification of H361 (suspected of damaging fertility or the unborn child) on ECHA, which supports a ‘suspected’ reproductive hazard (h=2). A recent peer‑reviewed rat study showed that systemic exposure to clotrimazole altered maternal and fetal steroid hormone profiles via CYP/steroidogenesis inhibition (demonstrated mechanism → m=2). For typical topical/vaginal cosmetic/OTC use systemic absorption is minimal but measurable, so exposure from topical cosmetic use is rated low (e=1). Sources: ECHA harmonised classification and PubMed study, plus product labeling on animal effects.
- Безопасен ли clotrimazole при грудном вскармливании?
- Harmonised H361 classification and animal data (CYP inhibition and steroid changes) provide evidence for a suspected reproductive/developmental hazard (h=2) and a demonstrated mechanistic effect (m=2). Topical use shows minimal but measurable systemic absorption and is therefore given low exposure (e=1); breastfeeding guidance notes limited systemic exposure with topical use but advises use only if benefits outweigh risks in some labels.
- Безопасен ли clotrimazole для кожи малыша?
- Hazard (h=2) remains based on harmonised H361 and animal evidence; mechanism (m=2) is the same (CYP/steroidogenesis effects demonstrated in animals). Exposure is increased by one band for infants because infant skin has higher absorption — adult topical e=1 → baby e=2 (measurable/moderate exposure potential for 0–3 yr). There is limited infant‑specific reproductive/toxicity data; topical clotrimazole has been used in infants in clinical studies but systemic safety data are limited.
- Как VeriMom оценивает clotrimazole?
- VeriMom оценивает clotrimazole в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы clotrimazole при беременности?
- См. наш список безопасных альтернатив clotrimazole с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.