VeriMomСтоит ли избегать basic green 4 при беременности? | VeriMom
ECHA has a harmonised CLP entry for malachite green (Basic Green 4, CAS 569-64-2) with a reproductive/developmental suspect classification (H361d — 'suspected of damaging the unborn child'), so reproductive hazard is judged as 'suspected'. Animal and in vitro studies report developmental effects and show that the metabolite leucomalachite green (LMG) is present in dam plasma and amniotic fluid, supporting a plausible mechanism (placental exposure). Topical/cosmetic exposure would likely give low but measurable systemic exposure if used, so exposure score is 1. (ECHA Annex/CLP; rat developmental study).
ECHA regulatory hazard statements
- •H361
- •H361D
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Безопасен ли basic green 4 при беременности?
- ECHA has a harmonised CLP entry for malachite green (Basic Green 4, CAS 569-64-2) with a reproductive/developmental suspect classification (H361d — 'suspected of damaging the unborn child'), so reproductive hazard is judged as 'suspected'. Animal and in vitro studies report developmental effects and show that the metabolite leucomalachite green (LMG) is present in dam plasma and amniotic fluid, supporting a plausible mechanism (placental exposure). Topical/cosmetic exposure would likely give low but measurable systemic exposure if used, so exposure score is 1. (ECHA Annex/CLP; rat developmental study).
- Безопасен ли basic green 4 при грудном вскармливании?
- Harmonised classification for developmental hazard (H361d) and animal data demonstrating maternal systemic exposure and placental/biological transfer (LMG detected in amniotic fluid) indicate suspected risk to the developing offspring; while direct human lactation studies are lacking, demonstrated maternal systemic absorption/metabolism supports a plausible mechanism for transfer into milk. Typical topical cosmetic use would likely give low but measurable maternal exposure (score 1).
- Безопасен ли basic green 4 для кожи малыша?
- Hazard (H361d) and animal developmental/toxicity data justify the same hazard score for infant skin exposure (do not escalate h/m without infant-specific toxicity data). Mechanistic evidence (LMG in maternal plasma/amniotic fluid) supports m=2. Because infant skin has higher absorption/surface-area-to-weight, exposure score is increased by +1 versus adult topical (adult e=1 → infant e=2). Note: the substance is listed as prohibited in EU cosmetic Annex II / disallowed in baby products in multiple lists, reflecting regulatory precaution.
- Как VeriMom оценивает basic green 4?
- VeriMom оценивает basic green 4 в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
- Какие безопасные альтернативы basic green 4 при беременности?
- См. наш список безопасных альтернатив basic green 4 с аналогичной функцией и классификацией без известных рисков.
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Медицинская оговорка
Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.