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Стоит ли избегать basic blue 9 при беременности? | VeriMom

Methylene blue (Basic Blue 9, CAS 61-73-4) is associated with documented fetal harm after intra‑amniotic exposure (case series of jejuno‑ileal/intestinal atresia and fetal death); regulatory/clinical sources note teratogenic risk and recommend avoiding intra‑amniotic use in pregnancy. ECHA record references a harmonised/suspected reproduction hazard (H361) for this substance, and clinical teratology reviews/monographs (UKTIS, StatPearls, PubMed case reports) describe the fetal risks. Topical cosmetic use would give low but measurable systemic exposure only, so pregnancy exposure from normal topical use is judged low but not zero. (Sources: ECHA substance info; UKTIS monograph; PubMed case reports; StatPearls.)

ECHA regulatory hazard statements

  • H361

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли basic blue 9 при беременности?
Methylene blue (Basic Blue 9, CAS 61-73-4) is associated with documented fetal harm after intra‑amniotic exposure (case series of jejuno‑ileal/intestinal atresia and fetal death); regulatory/clinical sources note teratogenic risk and recommend avoiding intra‑amniotic use in pregnancy. ECHA record references a harmonised/suspected reproduction hazard (H361) for this substance, and clinical teratology reviews/monographs (UKTIS, StatPearls, PubMed case reports) describe the fetal risks. Topical cosmetic use would give low but measurable systemic exposure only, so pregnancy exposure from normal topical use is judged low but not zero. (Sources: ECHA substance info; UKTIS monograph; PubMed case reports; StatPearls.)
Безопасен ли basic blue 9 при грудном вскармливании?
There are no strong human data specifically about transfer into breast milk, but given systemic use can produce fetal/ neonatal effects and that methylene blue is systemically active, a conservative rating is maintained (suspected reproductive hazard). Clinical guidance cautions use in pregnancy; breastfeeding exposure potential is unknown but systemic maternal exposure could result in transfer—therefore exposure from typical topical cosmetic use is likely low but measurable. (Sources: UKTIS, StatPearls, PubMed case literature.)
Безопасен ли basic blue 9 для кожи малыша?
Infant-specific evidence of increased sensitivity is lacking; however because the ingredient has measurable absorption in humans and is systemically active, the exposure score for baby skin is increased by +1 versus adult (immature barrier and higher surface‑area:weight). No infant‑topical studies showing unique teratogenicity were found, so hazard/mechanism scores are not increased beyond the pregnancy assessment. (Sources: PubMed case reports; UKTIS; general toxicology summaries.)
Как VeriMom оценивает basic blue 9?
VeriMom оценивает basic blue 9 в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.
Какие безопасные альтернативы basic blue 9 при беременности?
См. наш список безопасных альтернатив basic blue 9 с аналогичной функцией и классификацией без известных рисков.

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Медицинская оговорка

Данная информация предоставлена исключительно в образовательных целях и не является медицинской рекомендацией. Оценки безопасности основаны на общедоступных данных и могут не отражать все риски. Всегда консультируйтесь с вашим врачом перед использованием любых средств во время беременности или грудного вскармливания.

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