Стоит ли избегать 5-bromo-5-nitro-1,3-dioxane при беременности? | VeriMom

What to use instead

Pregnancy-safe ingredients that serve a similar function:

FAQ

Безопасен ли 5-bromo-5-nitro-1,3-dioxane при беременности?

Authoritative cosmetic reviews (CIR references) and regulatory reviews do not report convincing reproductive or teratogenic effects for 5-bromo-5-nitro-1,3-dioxane (bronidox); some sources report negative Ames tests and no clear repro/mutagenicity in the limited data available. Although some C&L notifications list H361 (suspected of damaging fertility or the unborn child), I could not find a harmonised Annex VI (legal) classification for this CAS — notifications/self-classifications alone do not raise the hazard score under your rules. Exposure from intended cosmetic topical use is low (used as a cosmetic preservative at up to ~0.1%, mainly in rinse-off products), so I scored exposure as 1 (low but measurable). Sources: CIR/regulatory reviews and ECHA registration/brief profile and reports cited below.

Безопасен ли 5-bromo-5-nitro-1,3-dioxane при грудном вскармливании?

No specific data were found showing reproductive or lactation-specific toxicity or transfer into breast milk. Mechanistic or experimental evidence of breast‑milk transfer is absent in the reviewed sources; therefore hazard and mechanism are scored 0 and exposure is scored 1 (low but measurable) for typical cosmetic topical use. See sources below for preservative use, regulatory restrictions and toxicology summaries.

Безопасен ли 5-bromo-5-nitro-1,3-dioxane для кожи малыша?

There is no infant-specific reproductive or developmental toxicity evidence. However, because bronidox is a small preservative used topically (and is reported to be skin‑irritating / a sensitizer at higher concentrations) I increased exposure by +1 for infants (immature barrier and higher surface-area-to-weight); this gives e=2. There is no infant-specific data to justify increasing hazard (h) or mechanism (m). Also note regulatory guidance restricts use to rinse‑off products and maximum concentrations (see sources).

Как VeriMom оценивает 5-bromo-5-nitro-1,3-dioxane?

VeriMom оценивает 5-bromo-5-nitro-1,3-dioxane в 33/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы 5-bromo-5-nitro-1,3-dioxane при беременности?

См. наш список безопасных альтернатив 5-bromo-5-nitro-1,3-dioxane с аналогичной функцией и классификацией без известных рисков.