Стоит ли избегать 4-t-butylbenzoic acid при беременности? | VeriMom

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FAQ

Безопасен ли 4-t-butylbenzoic acid при беременности?

ECHA’s Annex VI proposal and supporting Annex VI report list a harmonised classification Repr. 1B (H360F — “may damage fertility”) for 4‑tert‑butylbenzoic acid (CAS 98‑73‑7), and the report summarizes multiple animal studies showing testicular toxicity and impaired male fertility in rats; this is the legal/authoritative basis for a confirmed reproductive hazard. (ECHA Annex VI report; ECHA substance page).

Безопасен ли 4-t-butylbenzoic acid при грудном вскармливании?

Because the substance has a harmonised reproductive classification (H360F) based on animal data indicating effects on fertility and testes, the hazard is carried over to breastfeeding consideration (potential for systemic maternal toxicity and transfer). No breastfeeding‑specific mechanistic data were located. (ECHA Annex VI report; ECHA substance page).

Безопасен ли 4-t-butylbenzoic acid для кожи малыша?

Hazard remains H360F per harmonised classification (no infant‑specific data to change h or m). Dermal absorption data in the ECHA dossier and toxicokinetic discussion indicate systemic availability; infant skin has higher exposure potential, so exposure score is increased by +1 for 0–3 yr old skin. No infant dermal toxicology studies were found. (ECHA Annex VI report; ECHA registration/substance pages).

Как VeriMom оценивает 4-t-butylbenzoic acid?

VeriMom оценивает 4-t-butylbenzoic acid в 27/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы 4-t-butylbenzoic acid при беременности?

См. наш список безопасных альтернатив 4-t-butylbenzoic acid с аналогичной функцией и классификацией без известных рисков.