Стоит ли избегать 2-hydroxyethyl picramic acid при беременности? | VeriMom

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FAQ

Безопасен ли 2-hydroxyethyl picramic acid при беременности?

ECHA lists a harmonised CLP classification for 2-hydroxyethyl picramic acid (Index No. 604-056-00-2, CAS 99610-72-7) including H361f (suspected of damaging fertility), which per EU harmonised CLP guidance is a Category 2 reproductive hazard (supports h=2). Peer-review/regulatory assessments (SCCS/CIR/IMAP/TGA summaries) report animal data and testicular effects, indicating a demonstrated reproductive mechanism (m=2). Topical exposure from hair-dye use is low but measurable (SCCS evaluated on-head limits such as 0.6% and concluded risk mainly from sensitisation), so exposure for pregnant adults from cosmetic use is assessed as low but measurable (e=1).

Безопасен ли 2-hydroxyethyl picramic acid при грудном вскармливании?

Harmonised CLP H361f applies; regulatory reviews cite reproductive toxicity in animals (m=2) and harmonised classification carries to concerns for breastfeeding parents. Topical cosmetic use gives low but measurable exposure (SCCS on-head limits), so e=1 for lactating adults. There are no specific data showing transfer into breastmilk identified in the reviewed sources (data gap).

Безопасен ли 2-hydroxyethyl picramic acid для кожи малыша?

Hazard (H361f harmonised) and reported animal reproductive/testicular effects justify h=2 for infant-related concern under the requested scoring system. Mechanistic evidence from animal reproductive toxicology supports m=2. Because infant skin (0–3 yr) has a higher surface‑area:weight and an immature barrier, exposure score is increased by +1 relative to adults (adult e=1 → infant e=2) where topically applied products or accidental exposure could occur. No infant-specific absorption studies were found. (See data gaps.)

Как VeriMom оценивает 2-hydroxyethyl picramic acid?

VeriMom оценивает 2-hydroxyethyl picramic acid в 20/100 (высокий риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы 2-hydroxyethyl picramic acid при беременности?

См. наш список безопасных альтернатив 2-hydroxyethyl picramic acid с аналогичной функцией и классификацией без известных рисков.