Question 1

Is (angelica keiskei/chrysanthemum zawadskii) leaf/stem/cinnamomum cassia bark/trichosantes kirilowii fruit/ulmus davidiana bark/root/(paeonia japonica/bupleurum falcatum/polygala tenuifolia root)/viscus album stem extract safe during pregnancy?

Accepted Answer

No EU Annex II/III listing found for the listed plant extracts. The only ingredient in the list with notable regulatory attention is cinnamomum cassia (cinnamon) whose main constituent cinnamaldehyde is under an ECHA CLH (harmonised classification & labelling) proposal process (April 2025 consultation) but is not (to our documentation) harmonised as H360/H361; therefore the evidence does not support h≥2. Several components have published bioactivity/toxicity signals in the literature (Viscum album — cautioned in pregnancy by NCCIH; Trichosanthes kirilowii — recent toxicology work including teratogenicity endpoints in preclinical assessments; Polygala tenuifolia — genotoxicity studies reported). Those findings indicate plausible mechanisms (in vitro bioactivity, genotoxicity signals) so assign m=1 (demonstrated in vitro/animal signals but not a well‑characterized reproductive mechanism in humans) and h=1 (structural/class-based or limited animal/phyto warnings). Topical cosmetic exposure is expected to give low but measurable systemic exposure for constituents like cinnamaldehyde; therefore e=1 for adult topical use.

Question 2

Is (angelica keiskei/chrysanthemum zawadskii) leaf/stem/cinnamomum cassia bark/trichosantes kirilowii fruit/ulmus davidiana bark/root/(paeonia japonica/bupleurum falcatum/polygala tenuifolia root)/viscus album stem extract safe while breastfeeding?

Accepted Answer

No harmonised CMR or Annex II/III restrictions found specific to these cosmetic extracts. Some components (Viscum album) are flagged as unsafe for internal use in pregnancy/lactation in authoritative guidance (NCCIH) and some botanical constituents have demonstrated bioactivity in vitro/animals; this supports a precautionary low-level hazard rating (h=1) and mechanism rating (m=1). Topical exposure during breastfeeding is expected to be low but measurable for some small lipophilic constituents (e.g., cinnamaldehyde), so e=1.

Question 3

Is (angelica keiskei/chrysanthemum zawadskii) leaf/stem/cinnamomum cassia bark/trichosantes kirilowii fruit/ulmus davidiana bark/root/(paeonia japonica/bupleurum falcatum/polygala tenuifolia root)/viscus album stem extract safe for baby skin?

Accepted Answer

No EU ban/restriction or harmonised H360/H361 found for the named extracts as cosmetic ingredients. Because several constituents show bioactivity or toxicology signals in preclinical work (Polygala genotoxicity, Trichosanthes toxicology studies, mistletoe reproductive cautions) a conservative but evidence-based h=1 and m=1 are used. Exposure score increased by +1 for baby skin (adult e=1 → infant e=2) due to immature barrier and higher surface-area-to-weight, increasing likelihood of measurable systemic uptake of small active constituents (for example cinnamaldehyde and other low‑MW phytochemicals). Avoid application to broken skin and limit use on infants until ingredient-specific safety data for topical use on infants are available.

Question 4

How does VeriMom score (angelica keiskei/chrysanthemum zawadskii) leaf/stem/cinnamomum cassia bark/trichosantes kirilowii fruit/ulmus davidiana bark/root/(paeonia japonica/bupleurum falcatum/polygala tenuifolia root)/viscus album stem extract?

Accepted Answer

VeriMom scores (angelica keiskei/chrysanthemum zawadskii) leaf/stem/cinnamomum cassia bark/trichosantes kirilowii fruit/ulmus davidiana bark/root/(paeonia japonica/bupleurum falcatum/polygala tenuifolia root)/viscus album stem extract at 67/100 (medium risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.

Question 5

What are pregnancy-safe alternatives to (angelica keiskei/chrysanthemum zawadskii) leaf/stem/cinnamomum cassia bark/trichosantes kirilowii fruit/ulmus davidiana bark/root/(paeonia japonica/bupleurum falcatum/polygala tenuifolia root)/viscus album stem extract?

Accepted Answer

See our curated list of pregnancy-safe alternatives to (angelica keiskei/chrysanthemum zawadskii) leaf/stem/cinnamomum cassia bark/trichosantes kirilowii fruit/ulmus davidiana bark/root/(paeonia japonica/bupleurum falcatum/polygala tenuifolia root)/viscus album stem extract based on similar function and a no-known-risks safety band.

(angelica keiskei/chrysanthemum zawadskii) leaf/stem/cinnamomum cassia bark/trichosantes kirilowii fruit/ulmus davidiana bark/root/(paeonia japonica/bupleurum falcatum/polygala tenuifolia root)/viscus album stem extract

Regulatory Data

Sources & references

Pregnancy-Safe Alternatives to (angelica keiskei/chrysanthemum zawadskii) leaf/stem/cinnamomum cassia bark/trichosantes kirilowii fruit/ulmus davidiana bark/root/(paeonia japonica/bupleurum falcatum/polygala tenuifolia root)/viscus album stem extract | VeriMom

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