VeriMomSollte ich trimethyl pentanyl diisobutyrate in der Schwangerschaft meiden? | VeriMom
Trimethyl pentanyl diisobutyrate (TXIB; CAS 6846-50-0) has a harmonised/suspected reproductive hazard classification (H361) in regulatory sources and registration dossiers reporting reduced implant numbers and reduced litter weights in an OECD 421 rat study, supporting a suspected reproductive hazard. (ECHA registration dossier and SDS reporting H361; see sources). In vitro and ex vivo studies (fetal testis organ culture; gonadal cell lines) show biologically plausible effects on reproductive endpoints/sex-hormone related parameters, indicating a demonstrated mechanistic signal. Topical cosmetic exposure would generally give low but measurable systemic exposure (so e=1) for pregnant adults absent product-specific dermal absorption data.
ECHA regulatory hazard statements
- •H361
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FAQ
- Ist trimethyl pentanyl diisobutyrate in der Schwangerschaft sicher?
- Trimethyl pentanyl diisobutyrate (TXIB; CAS 6846-50-0) has a harmonised/suspected reproductive hazard classification (H361) in regulatory sources and registration dossiers reporting reduced implant numbers and reduced litter weights in an OECD 421 rat study, supporting a suspected reproductive hazard. (ECHA registration dossier and SDS reporting H361; see sources). In vitro and ex vivo studies (fetal testis organ culture; gonadal cell lines) show biologically plausible effects on reproductive endpoints/sex-hormone related parameters, indicating a demonstrated mechanistic signal. Topical cosmetic exposure would generally give low but measurable systemic exposure (so e=1) for pregnant adults absent product-specific dermal absorption data.
- Ist trimethyl pentanyl diisobutyrate während des Stillens sicher?
- Same hazard basis applies (harmonised H361 / OECD 421 reproductive findings). Mechanistic data (in vitro/ex vivo endocrine-related effects and interactions with sex-hormone binding protein) support potential for reproductive/endocrine activity. With typical topical cosmetic use, maternal systemic exposure is expected to be low but measurable; specific data on transfer into human milk are not available, so exposure is scored as low (e=1).
- Ist trimethyl pentanyl diisobutyrate sicher für Babyhaut?
- Hazard and mechanistic evidence remain the same (H361; animal reproductive/developmental signals; in vitro/ex vivo endocrine-related findings). Infant skin has higher absorption per kg, so exposure score is increased by +1 versus adults (adult e=1 → baby e=2) in the absence of definitive dermal absorption data for cosmetic formulations intended for infants.
- Wie bewertet VeriMom trimethyl pentanyl diisobutyrate?
- VeriMom bewertet trimethyl pentanyl diisobutyrate mit 20/100 (hohes Risiko) basierend auf EU CosIng, ECHA-Klassifizierungen und PubMed-Studien.
- Was sind schwangerschaftssichere Alternativen zu trimethyl pentanyl diisobutyrate?
- Siehe unsere kuratierte Liste der schwangerschaftssicheren Alternativen zu trimethyl pentanyl diisobutyrate basierend auf ähnlicher Funktion.
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Medizinischer Haftungsausschluss
Diese Informationen dienen ausschließlich Bildungszwecken und stellen keine medizinische Beratung dar. Sicherheitsbewertungen basieren auf öffentlich zugänglichen Daten und spiegeln möglicherweise nicht alle Risiken wider. Konsultieren Sie immer Ihren Arzt, bevor Sie ein Produkt während der Schwangerschaft oder Stillzeit verwenden.