VeriMomSollte ich pentetic acid in der Schwangerschaft meiden? | VeriMom
Diethylenetriaminepentaacetic acid (pentetic acid, DTPA; CAS 67-43-6) has an EU harmonised classification Repr.1B H360D in Annex VI (legal, harmonised CLP), so by regulatory calibration this is a confirmed reproductive hazard (h=3). The likely mechanism is demonstrated chelation of essential metals (e.g., zinc) with resulting developmental effects in animal studies (m=2). For typical topical cosmetic use, DTPA is a highly polar chelator with low expected dermal absorption, so exposure from normal dermal application is expected to be negligible (e=0). Sources: EU delegated regulation / Annex VI listing (Repr.1B H360D). (See EUR-Lex and ECHA).
ECHA regulatory hazard statements
- •H360D
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Ist pentetic acid in der Schwangerschaft sicher?
- Diethylenetriaminepentaacetic acid (pentetic acid, DTPA; CAS 67-43-6) has an EU harmonised classification Repr.1B H360D in Annex VI (legal, harmonised CLP), so by regulatory calibration this is a confirmed reproductive hazard (h=3). The likely mechanism is demonstrated chelation of essential metals (e.g., zinc) with resulting developmental effects in animal studies (m=2). For typical topical cosmetic use, DTPA is a highly polar chelator with low expected dermal absorption, so exposure from normal dermal application is expected to be negligible (e=0). Sources: EU delegated regulation / Annex VI listing (Repr.1B H360D). (See EUR-Lex and ECHA).
- Ist pentetic acid während des Stillens sicher?
- Harmonised Repr.1B (H360D) classification applies regardless of exposure route and therefore is used here (h=3). Mechanistic concern is the same (chelating-induced essential metal depletion shown in animals; m=2). With normal topical cosmetic use, systemic transfer into breastmilk is unlikely because dermal absorption is expected to be very low (e=0), but harmonised classification still indicates potential hazard if systemic exposures occur. Sources: EUR-Lex Annex VI; animal/ mechanistic literature on chelators and developmental effects.
- Ist pentetic acid sicher für Babyhaut?
- Because DTPA has a harmonised Repr.1B classification (H360D), the hazard score for infants remains h=3 (do not downgrade). Mechanistically the same chelation-mediated developmental/reproductive concern applies (m=2). Adult dermal absorption is expected to be minimal, but infant skin has higher surface-area-to-weight and immature barrier; per the scoring rules this increases exposure by +1 (adult e=0 → baby e=1) unless reliable dermal non-absorption data exist. Therefore exposure for babies via topical products is scored e=1. Sources: EUR-Lex Annex VI (harmonised CLP), ECHA substance information, and literature on chelators’ developmental effects.
- Wie bewertet VeriMom pentetic acid?
- VeriMom bewertet pentetic acid mit 27/100 (hohes Risiko) basierend auf EU CosIng, ECHA-Klassifizierungen und PubMed-Studien.
- Was sind schwangerschaftssichere Alternativen zu pentetic acid?
- Siehe unsere kuratierte Liste der schwangerschaftssicheren Alternativen zu pentetic acid basierend auf ähnlicher Funktion.
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Medizinischer Haftungsausschluss
Diese Informationen dienen ausschließlich Bildungszwecken und stellen keine medizinische Beratung dar. Sicherheitsbewertungen basieren auf öffentlich zugänglichen Daten und spiegeln möglicherweise nicht alle Risiken wider. Konsultieren Sie immer Ihren Arzt, bevor Sie ein Produkt während der Schwangerschaft oder Stillzeit verwenden.