Sollte ich cis-retinoic acid in der Schwangerschaft meiden? | VeriMom
13‑cis‑retinoic acid (isotretinoin, CAS 4759‑48‑2) is a well‑established human teratogen when given systemically (oral isotretinoin causes severe, characteristic birth defects) and is regulated as a pregnancy‑contraindicated retinoid; the teratogenic mechanism is well characterized via retinoic‑acid / retinoid receptor signalling. Topical use gives lower systemic exposure than oral dosing but measurable absorption has been reported for topical retinoids and regulatory guidance treats retinoic acid/isotretinoin as a pregnancy risk. ([fda.gov](https://www.fda.gov/media/166611/download?utm_source=openai))
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FAQ
- Ist cis-retinoic acid in der Schwangerschaft sicher?
- 13‑cis‑retinoic acid (isotretinoin, CAS 4759‑48‑2) is a well‑established human teratogen when given systemically (oral isotretinoin causes severe, characteristic birth defects) and is regulated as a pregnancy‑contraindicated retinoid; the teratogenic mechanism is well characterized via retinoic‑acid / retinoid receptor signalling. Topical use gives lower systemic exposure than oral dosing but measurable absorption has been reported for topical retinoids and regulatory guidance treats retinoic acid/isotretinoin as a pregnancy risk. ([fda.gov](https://www.fda.gov/media/166611/download?utm_source=openai))
- Ist cis-retinoic acid während des Stillens sicher?
- Oral isotretinoin is contraindicated in breastfeeding because of concern for systemic exposure to the infant; the biological mechanism (retinoid receptor activity) is the same as for pregnancy. For topical cosmetic use, systemic transfer into milk is expected to be low but not zero, so breastfeeding exposure is considered low but not negligible. ([fda.gov](https://www.fda.gov/media/166611/download?utm_source=openai))
- Ist cis-retinoic acid sicher für Babyhaut?
- There is no infant‑specific evidence that topical cis‑retinoic acid applied to baby skin produces developmental/teratogenic effects (do not upgrade h/m without direct data). However infant skin has higher absorption (immature barrier and higher surface‑area‑to‑weight), so exposure scoring is increased relative to adults if the ingredient is present or applied directly. Topical retinoids are generally discouraged on young children because of irritancy and potential systemic uptake. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32643315/?utm_source=openai))
- Wie bewertet VeriMom cis-retinoic acid?
- VeriMom bewertet cis-retinoic acid mit 7/100 (hohes Risiko) basierend auf EU CosIng, ECHA-Klassifizierungen und PubMed-Studien.
- Was sind schwangerschaftssichere Alternativen zu cis-retinoic acid?
- Siehe unsere kuratierte Liste der schwangerschaftssicheren Alternativen zu cis-retinoic acid basierend auf ähnlicher Funktion.
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Medizinischer Haftungsausschluss
Diese Informationen dienen ausschließlich Bildungszwecken und stellen keine medizinische Beratung dar. Sicherheitsbewertungen basieren auf öffentlich zugänglichen Daten und spiegeln möglicherweise nicht alle Risiken wider. Konsultieren Sie immer Ihren Arzt, bevor Sie ein Produkt während der Schwangerschaft oder Stillzeit verwenden.