Sollte ich aminoguanidine bicarbonate in der Schwangerschaft meiden? | VeriMom
Harmonised EU classification for aminoguanidinium hydrogen carbonate (CAS 2582-30-1) lists Reproductive toxicity Category 1B (H360), which indicates presumed human reproductive toxicity (ECHA). Animal/experimental studies with aminoguanidine report fetal developmental effects in rodents (fetal toxicity, growth effects), and aminoguanidine is a biologically active iNOS inhibitor affecting nitric oxide pathways relevant to pregnancy, supporting a demonstrated mechanism. Topical cosmetic exposure would likely give low but measurable systemic exposure for adults (no data showing negligible/permanent non-absorption). ([echa.europa.eu](https://echa.europa.eu/brief-profile/-/briefprofile/100.018.143?utm_source=openai))
ECHA regulatory hazard statements
- •H360
What to use instead
Pregnancy-safe ingredients that serve a similar function:
FAQ
- Ist aminoguanidine bicarbonate in der Schwangerschaft sicher?
- Harmonised EU classification for aminoguanidinium hydrogen carbonate (CAS 2582-30-1) lists Reproductive toxicity Category 1B (H360), which indicates presumed human reproductive toxicity (ECHA). Animal/experimental studies with aminoguanidine report fetal developmental effects in rodents (fetal toxicity, growth effects), and aminoguanidine is a biologically active iNOS inhibitor affecting nitric oxide pathways relevant to pregnancy, supporting a demonstrated mechanism. Topical cosmetic exposure would likely give low but measurable systemic exposure for adults (no data showing negligible/permanent non-absorption). ([echa.europa.eu](https://echa.europa.eu/brief-profile/-/briefprofile/100.018.143?utm_source=openai))
- Ist aminoguanidine bicarbonate während des Stillens sicher?
- Because the substance has an EU harmonised classification as Repr.1B (H360), the hazard score for breastfeeding is aligned with pregnancy (h=3). The mechanism (iNOS inhibition; demonstrated biological activity) supports potential effects on reproductive/offspring endpoints; no specific lactation transfer data were found, so adult topical exposure is assumed to give low but measurable systemic levels absent formulation-specific data. ([echa.europa.eu](https://echa.europa.eu/brief-profile/-/briefprofile/100.018.143?utm_source=openai))
- Ist aminoguanidine bicarbonate sicher für Babyhaut?
- Harmonised Repr.1B classification (H360) applies irrespective of age; therefore hazard remains h=3 for infant skin contact. Mechanistic evidence (aminoguanidine biological activity) is applicable. Exposure rating is increased by +1 for baby skin because aminoguanidine is a small, water‑soluble molecule with measurable absorption potential; infant skin has higher absorption per weight, so exposure is likely moderate relative to adults in the absence of specific dermal absorption/formulation data. ([echa.europa.eu](https://echa.europa.eu/brief-profile/-/briefprofile/100.018.143?utm_source=openai))
- Wie bewertet VeriMom aminoguanidine bicarbonate?
- VeriMom bewertet aminoguanidine bicarbonate mit 20/100 (hohes Risiko) basierend auf EU CosIng, ECHA-Klassifizierungen und PubMed-Studien.
- Was sind schwangerschaftssichere Alternativen zu aminoguanidine bicarbonate?
- Siehe unsere kuratierte Liste der schwangerschaftssicheren Alternativen zu aminoguanidine bicarbonate basierend auf ähnlicher Funktion.
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Medizinischer Haftungsausschluss
Diese Informationen dienen ausschließlich Bildungszwecken und stellen keine medizinische Beratung dar. Sicherheitsbewertungen basieren auf öffentlich zugänglichen Daten und spiegeln möglicherweise nicht alle Risiken wider. Konsultieren Sie immer Ihren Arzt, bevor Sie ein Produkt während der Schwangerschaft oder Stillzeit verwenden.