Sollte ich 5-bromo-5-nitro-1,3-dioxane in der Schwangerschaft meiden? | VeriMom
Authoritative cosmetic reviews (CIR references) and regulatory reviews do not report convincing reproductive or teratogenic effects for 5-bromo-5-nitro-1,3-dioxane (bronidox); some sources report negative Ames tests and no clear repro/mutagenicity in the limited data available. Although some C&L notifications list H361 (suspected of damaging fertility or the unborn child), I could not find a harmonised Annex VI (legal) classification for this CAS — notifications/self-classifications alone do not raise the hazard score under your rules. Exposure from intended cosmetic topical use is low (used as a cosmetic preservative at up to ~0.1%, mainly in rinse-off products), so I scored exposure as 1 (low but measurable). Sources: CIR/regulatory reviews and ECHA registration/brief profile and reports cited below.
ECHA regulatory hazard statements
- •H361
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FAQ
- Ist 5-bromo-5-nitro-1,3-dioxane in der Schwangerschaft sicher?
- Authoritative cosmetic reviews (CIR references) and regulatory reviews do not report convincing reproductive or teratogenic effects for 5-bromo-5-nitro-1,3-dioxane (bronidox); some sources report negative Ames tests and no clear repro/mutagenicity in the limited data available. Although some C&L notifications list H361 (suspected of damaging fertility or the unborn child), I could not find a harmonised Annex VI (legal) classification for this CAS — notifications/self-classifications alone do not raise the hazard score under your rules. Exposure from intended cosmetic topical use is low (used as a cosmetic preservative at up to ~0.1%, mainly in rinse-off products), so I scored exposure as 1 (low but measurable). Sources: CIR/regulatory reviews and ECHA registration/brief profile and reports cited below.
- Ist 5-bromo-5-nitro-1,3-dioxane während des Stillens sicher?
- No specific data were found showing reproductive or lactation-specific toxicity or transfer into breast milk. Mechanistic or experimental evidence of breast‑milk transfer is absent in the reviewed sources; therefore hazard and mechanism are scored 0 and exposure is scored 1 (low but measurable) for typical cosmetic topical use. See sources below for preservative use, regulatory restrictions and toxicology summaries.
- Ist 5-bromo-5-nitro-1,3-dioxane sicher für Babyhaut?
- There is no infant-specific reproductive or developmental toxicity evidence. However, because bronidox is a small preservative used topically (and is reported to be skin‑irritating / a sensitizer at higher concentrations) I increased exposure by +1 for infants (immature barrier and higher surface-area-to-weight); this gives e=2. There is no infant-specific data to justify increasing hazard (h) or mechanism (m). Also note regulatory guidance restricts use to rinse‑off products and maximum concentrations (see sources).
- Wie bewertet VeriMom 5-bromo-5-nitro-1,3-dioxane?
- VeriMom bewertet 5-bromo-5-nitro-1,3-dioxane mit 33/100 (hohes Risiko) basierend auf EU CosIng, ECHA-Klassifizierungen und PubMed-Studien.
- Was sind schwangerschaftssichere Alternativen zu 5-bromo-5-nitro-1,3-dioxane?
- Siehe unsere kuratierte Liste der schwangerschaftssicheren Alternativen zu 5-bromo-5-nitro-1,3-dioxane basierend auf ähnlicher Funktion.
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Medizinischer Haftungsausschluss
Diese Informationen dienen ausschließlich Bildungszwecken und stellen keine medizinische Beratung dar. Sicherheitsbewertungen basieren auf öffentlich zugänglichen Daten und spiegeln möglicherweise nicht alle Risiken wider. Konsultieren Sie immer Ihren Arzt, bevor Sie ein Produkt während der Schwangerschaft oder Stillzeit verwenden.