Should I Avoid methylthiophenyl morpholino isobutanone During Pregnancy? | VeriMom

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Pregnancy-Safe Alternatives to methylthiophenyl morpholino isobutanone | VeriMom

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See also

• Is methylthiophenyl morpholino isobutanone safe during pregnancy?
• Is methylthiophenyl morpholino isobutanone safe for babies?
• What are pregnancy-safe alternatives to methylthiophenyl morpholino isobutanone?

FAQ

Is methylthiophenyl morpholino isobutanone safe during pregnancy?

This substance (2‑methyl‑1‑(4‑methylthiophenyl)‑2‑morpholinopropan‑1‑one; CAS 71868‑10‑5) has an EU harmonised CLP classification as Toxic for Reproduction Category 1B, H360FD (“May damage fertility. May damage the unborn child”), which places it in the highest reproductive hazard category and justifies h=3. ECHA’s supporting background/briefing documents and Annex VI entry report reproductive toxicity data from regulatory assessments (animal datasets) though a specific molecular mechanism is not fully characterised; therefore m=2 (demonstrated effect in studies). Topical cosmetic exposure data are limited and it has historically been used in non‑leave‑on products / industrial applications; in absence of quantitative dermal absorption data I score exposure as low but measurable (e=1). Sources: ECHA harmonised CLP / Annex VI recommendation and background documents, ECHA brief profile.

Is methylthiophenyl morpholino isobutanone safe while breastfeeding?

Harmonised H360FD (may damage fertility and the unborn child) indicates high reproductive hazard (h=3) and the regulatory dossier shows animal reproductive toxicity evidence (m=2). There are no public quantitative data on human milk transfer; exposure from typical topical cosmetic use is likely low but measurable (e=1) — breastfeeding concern derives from systemic hazard plus potential for maternal systemic exposure. Sources: ECHA harmonised classification and background documents.

Is methylthiophenyl morpholino isobutanone safe for baby skin?

Hazard (h=3) remains because of the substance’s harmonised H360FD reproduction/teratogenic classification. Mechanistic evidence remains regulatory/animal‑based rather than a well‑characterised molecular pathway (m=2). For infant skin (0–3 yr) exposure I increase exposure by +1 relative to adults (adult e=1 → baby e=2) because infant skin has higher surface‑area‑to‑weight and an immature barrier and there are no reliable dermal absorption data showing non‑absorbability. Together this yields higher concern for use on or near infants. Sources: ECHA harmonised CLP / background documents; PubChem substance record.

How does VeriMom score methylthiophenyl morpholino isobutanone?

VeriMom scores methylthiophenyl morpholino isobutanone at 20/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.

What are pregnancy-safe alternatives to methylthiophenyl morpholino isobutanone?

See our curated list of pregnancy-safe alternatives to methylthiophenyl morpholino isobutanone based on similar function and a no-known-risks safety band.