Should I Avoid bis-retinoyl gerotine bis-hydroxysuccinimide During Pregnancy? | VeriMom

What to use instead

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Pregnancy-safe products to use instead

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Pregnancy-Safe Alternatives to bis-retinoyl gerotine bis-hydroxysuccinimide | VeriMom

Ingredients — Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated

See also

• Is bis-retinoyl gerotine bis-hydroxysuccinimide safe during pregnancy?
• Is bis-retinoyl gerotine bis-hydroxysuccinimide safe for babies?
• What are pregnancy-safe alternatives to bis-retinoyl gerotine bis-hydroxysuccinimide?

FAQ

Is bis-retinoyl gerotine bis-hydroxysuccinimide safe during pregnancy?

Class-based reproductive/developmental concern: retinoids (vitamin A derivatives) are a known class with developmental/teratogenic effects; SCCS has updated guidance/restrictions for vitamin A in cosmetics. No evidence found that this specific CAS (666854-47-3) is harmonised as H360/H361 or listed in Annex II, but because it is a retinoyl derivative the conservative classification is 'suspected' reproductive hazard (h=2). Mechanism: retinoid / retinoic-acid receptor agonism is a well-characterised developmental mechanism (m=3). Exposure: topical retinoid derivatives have measurable dermal absorption in use; assign moderate exposure for adults (e=2). Sources: SCCS vitamin A opinion (EU), PubChem / cosmetic ingredient lists, supplier pages.

Is bis-retinoyl gerotine bis-hydroxysuccinimide safe while breastfeeding?

Reasoning mirrors pregnancy: systemic exposure after dermal application is plausible for retinoid derivatives and transfer into breastmilk is biologically plausible; no compound-specific breastfeeding data found. Mechanism same as pregnancy (retinoid receptor activity). Exposure scored moderate (e=2) given topical absorption; keep precautionary suspected hazard (h=2).

Is bis-retinoyl gerotine bis-hydroxysuccinimide safe for baby skin?

For infants (0–3 yr) increase exposure score by +1 because of immature barrier and higher surface-area-to-weight; thus e=3. Hazard (h=2) and mechanism (m=3) remain class-based suspected developmental/retinoid mechanism; no infant-specific safety data were found for this CAS. Use caution because retinoid exposure is more concerning in young children.

How does VeriMom score bis-retinoyl gerotine bis-hydroxysuccinimide?

VeriMom scores bis-retinoyl gerotine bis-hydroxysuccinimide at 27/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.

What are pregnancy-safe alternatives to bis-retinoyl gerotine bis-hydroxysuccinimide?

See our curated list of pregnancy-safe alternatives to bis-retinoyl gerotine bis-hydroxysuccinimide based on similar function and a no-known-risks safety band.