VeriMomShould I Avoid aziridine During Pregnancy? | VeriMom
Reviewed by VeriMom Editorial Team · Last reviewed
ECHA regulatory hazard statements
- •H350
What to use instead
Pregnancy-safe ingredients that serve a similar function:
Pregnancy-safe products to use instead
Products built around the safer ingredients above, scored "no known risks" or "low risk".
Sources & references
Authoritative references used to score this ingredient.
Pregnancy-Safe Alternatives to aziridine | VeriMom
Ingredients — Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
See also
FAQ
- Is aziridine safe during pregnancy?
- Aziridine (ethyleneimine, CAS 151-56-4) has harmonised/regulatory classifications and authoritative toxicology indicating mutagenic and carcinogenic properties (ECHA registration/C&L info, EPA/IRIS, IARC). Harmonised flags for reproductive hazard (suspected; H361 reported in regulatory sources) support 'suspected' reproductive hazard (h=2). The mechanism is well-supported as an alkylating/genotoxic agent (demonstrated genotoxicity/mutagenicity) so m=2. For topical exposure, aziridine is a small, reactive molecule with reported dermal absorption and clear systemic toxicity in occupational/animal data, so exposure from topical use would be at least measurable/moderate (e=2). Sources: ECHA dossier/C&L summaries, EPA IRIS/FACT sheet, NIOSH/NIH toxicology summaries, IARC summary.
- Is aziridine safe while breastfeeding?
- Same hazard and mechanism rationale as pregnancy (suspected reproductive/teratogenic risk via genotoxic/alkylating activity). No specific human lactation transfer data located, but systemic toxicity and dermal absorption reported in authoritative sources imply measurable maternal exposure and potential for transfer into breastmilk (therefore e=2).
- Is aziridine safe for baby skin?
- Hazard and mechanism as above (h=2, m=2). Because infant skin (0–3 yr) has higher surface-area-to-weight and an immature barrier, exposure score increases by +1 relative to adult topical exposure (adult e=2 → baby e=3). There is no infant-specific toxicokinetic evidence to change hazard or mechanism scores, only exposure.
- How does VeriMom score aziridine?
- VeriMom scores aziridine at 13/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to aziridine?
- See our curated list of pregnancy-safe alternatives to aziridine based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.