VeriMomShould I Avoid 4-t-butylbenzoic acid During Pregnancy? | VeriMom
Reviewed by VeriMom Editorial Team · Last reviewed
ECHA regulatory hazard statements
- •H360F
What to use instead
Pregnancy-safe ingredients that serve a similar function:
Pregnancy-safe products to use instead
Products built around the safer ingredients above, scored "no known risks" or "low risk".
Sources & references
Authoritative references used to score this ingredient.
Pregnancy-Safe Alternatives to 4-t-butylbenzoic acid | VeriMom
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FAQ
- Is 4-t-butylbenzoic acid safe during pregnancy?
- ECHA’s Annex VI proposal and supporting Annex VI report list a harmonised classification Repr. 1B (H360F — “may damage fertility”) for 4‑tert‑butylbenzoic acid (CAS 98‑73‑7), and the report summarizes multiple animal studies showing testicular toxicity and impaired male fertility in rats; this is the legal/authoritative basis for a confirmed reproductive hazard. (ECHA Annex VI report; ECHA substance page).
- Is 4-t-butylbenzoic acid safe while breastfeeding?
- Because the substance has a harmonised reproductive classification (H360F) based on animal data indicating effects on fertility and testes, the hazard is carried over to breastfeeding consideration (potential for systemic maternal toxicity and transfer). No breastfeeding‑specific mechanistic data were located. (ECHA Annex VI report; ECHA substance page).
- Is 4-t-butylbenzoic acid safe for baby skin?
- Hazard remains H360F per harmonised classification (no infant‑specific data to change h or m). Dermal absorption data in the ECHA dossier and toxicokinetic discussion indicate systemic availability; infant skin has higher exposure potential, so exposure score is increased by +1 for 0–3 yr old skin. No infant dermal toxicology studies were found. (ECHA Annex VI report; ECHA registration/substance pages).
- How does VeriMom score 4-t-butylbenzoic acid?
- VeriMom scores 4-t-butylbenzoic acid at 27/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to 4-t-butylbenzoic acid?
- See our curated list of pregnancy-safe alternatives to 4-t-butylbenzoic acid based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.