VeriMomHIGH RISK
Should I Avoid 4,4'-isopropylidenediphenol During Pregnancy? | VeriMom
Reviewed by VeriMom Editorial Team · Last reviewed
ECHA regulatory hazard statements
- •H360F
What to use instead
Pregnancy-safe ingredients that serve a similar function:
Pregnancy-safe products to use instead
Products built around the safer ingredients above, scored "no known risks" or "low risk".
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Sources & references
Authoritative references used to score this ingredient.
Pregnancy-Safe Alternatives to 4,4'-isopropylidenediphenol | VeriMom
Ingredients — Pregnancy-Safe Ingredients Database — 28,000+ Ingredients Rated
See also
FAQ
- Is 4,4'-isopropylidenediphenol safe during pregnancy?
- Bisphenol A (4,4'-isopropylidenediphenol) has a harmonised CLP classification including Repr. 1B (H360F) under ECHA Annex VI, which by calibration requires h=3. BPA is a demonstrated endocrine disruptor with evidence of placental/fetal transfer and fetal effects in animal and human-focused reviews (mechanism score m=2). For topical cosmetic use, dermal absorption is measurable but generally lower than dietary routes, so exposure for pregnant adults is scored as low-measurable (e=1).
- Is 4,4'-isopropylidenediphenol safe while breastfeeding?
- Harmonised Repr.1B (H360F) applies to BPA so h=3. BPA demonstrates endocrine activity and is transferred into breast milk; human biomonitoring and review literature document detectable BPA in breast milk and infant exposure (m=2). Because breastfeeding transfers systemic BPA to the infant (measured in milk and infant urine), exposure is moderate (e=2).
- Is 4,4'-isopropylidenediphenol safe for baby skin?
- The parent compound BPA carries harmonised H360F → h=3. Mechanistic evidence of endocrine activity and developmental effects supports m=2. For topical exposure to infants (0–3 yr) the exposure score is increased by +1 relative to adults due to immature skin and higher surface-area-to-weight; given measurable dermal absorption in adults (used in cosmetics) adult e=1 → infant e=2.
- How does VeriMom score 4,4'-isopropylidenediphenol?
- VeriMom scores 4,4'-isopropylidenediphenol at 20/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.
- What are pregnancy-safe alternatives to 4,4'-isopropylidenediphenol?
- See our curated list of pregnancy-safe alternatives to 4,4'-isopropylidenediphenol based on similar function and a no-known-risks safety band.
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Safety scores are based on publicly available data and may not reflect all risks. Always consult your healthcare provider before using any product during pregnancy or breastfeeding.