Безопасен ли tussilago farfara leaf extract при беременности?

Безопасные альтернативы tussilago farfara leaf extract при беременности | VeriMom

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Безопасен ли tussilago farfara leaf extract при беременности?

Tussilago farfara extracts are known to contain hepatotoxic and genotoxic pyrrolizidine alkaloids; animal studies show tumorigenicity and case reports link PA‑containing herbal use in pregnancy to infant liver damage, supporting a suspected reproductive/ developmental hazard (h=2). Evidence indicates a demonstrated toxic mechanism for PAs (genotoxic/hepatotoxic) rather than a purely theoretical structural alert (m=2). For topical cosmetic use, systemic exposure is expected to be low but measurable if PAs are present in the extract (e=1). (ECHA substance entry; PubMed carcinogenicity study; EFSA/PA reviews).

Безопасен ли tussilago farfara leaf extract при грудном вскармливании?

Same hazard drivers apply during lactation—PAs are hepatotoxic/genotoxic and have been implicated in neonatal/infant liver injury after maternal herbal use. Mechanistic data for PA toxicity apply (m=2). Topical use would generally give low but potentially measurable systemic exposure (e=1), so transfer in milk is plausible if maternal systemic levels occur. (ECHA; EFSA PA opinion; case reports and toxicology literature).

Безопасен ли tussilago farfara leaf extract для кожи малыша?

No infant‑specific studies found, so hazard and mechanism remain those from PA toxicity (h=2, m=2). Because infant skin has higher absorption (immature barrier, higher surface‑area:weight) and PAs are small molecule toxins that can be systemically available, exposure score is increased by +1 relative to adult topical use (adult e=1 → baby e=2). No data justify raising hazard or mechanism beyond adult scores. (EFSA/PA reviews; toxicology literature).

Как VeriMom оценивает tussilago farfara leaf extract?

VeriMom оценивает tussilago farfara leaf extract в 40/100 (средний риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы tussilago farfara leaf extract при беременности?

См. наш список безопасных альтернатив tussilago farfara leaf extract с аналогичной функцией и классификацией без известных рисков.