Безопасен ли vitex agnus castus extract при беременности?

Безопасные альтернативы vitex agnus castus extract при беременности | VeriMom

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Безопасен ли vitex agnus castus extract при беременности?

Multiple regulatory reviews and clinical reviews recommend avoiding Vitex agnus‑castus during pregnancy because the botanical has demonstrated effects on reproductive hormones (prolactin/progestogenic activity) and at least one animal study reported adverse pregnancy outcomes, so it is classed as 'suspected' reproductive hazard rather than confirmed harmonised CMR. (see TGA/EMA guidance; systematic review and PubMed animal study). Sources: TGA safety notice; systematic review/DARE; rat study. https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/vitex-agnus-castus, https://www.ncbi.nlm.nih.gov/books/NBK71283/, https://pubmed.ncbi.nlm.nih.gov/35837144/

Безопасен ли vitex agnus castus extract при грудном вскармливании?

Authoritative breastfeeding resources and reviews (LactMed / safety reviews) advise avoiding Vitex in lactation because it alters prolactin and may affect milk production and infant hormone exposure; this demonstrates a mechanistic concern (endocrine activity) and justifies a 'suspected' hazard score. Dermal/topical cosmetic use gives low systemic exposure but transfer into breastmilk is plausible with systemic administration; topical exposure is likely lower. Sources: LactMed (Chasteberry), systematic reviews, regulatory advisories. https://www.ncbi.nlm.nih.gov/books/NBK501807/, https://www.ncbi.nlm.nih.gov/books/NBK71283/

Безопасен ли vitex agnus castus extract для кожи малыша?

No direct evidence shows teratogenicity or infant‑skin specific reproductive toxicity from topical Vitex extracts, but the ingredient contains hormone‑active constituents (flavonoids, diterpenoids) which create a theoretical/class‑based concern for infants (hence h=1, m=1). Because infant skin has higher permeability, exposure score is increased by +1 relative to adult topical use (adult e=1 → infant e=2). Sources: phytochemistry summaries and reviews; translational guidance on avoiding systemic hormone modulators for infants. https://en.wikipedia.org/wiki/Vitex_agnus-castus, https://phcogrev.com/article/2018/12/23/104103phrevphrev2217

Как VeriMom оценивает vitex agnus castus extract?

VeriMom оценивает vitex agnus castus extract в 40/100 (средний риск) на основе EU CosIng, классификаций ECHA и исследований PubMed.

Какие безопасные альтернативы vitex agnus castus extract при беременности?

См. наш список безопасных альтернатив vitex agnus castus extract с аналогичной функцией и классификацией без известных рисков.